Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Periodic Flows in Microfluidics
Small ( IF 13.0 ) Pub Date : 2024-09-09 , DOI: 10.1002/smll.202404685 Amith Mudugamuwa 1 , Uditha Roshan 1 , Samith Hettiarachchi 1 , Haotian Cha 1 , Hafiz Musharaf 1 , Xiaoyue Kang 1 , Quang Thang Trinh 1 , Huan Ming Xia 2 , Nam-Trung Nguyen 1 , Jun Zhang 1, 3
Small ( IF 13.0 ) Pub Date : 2024-09-09 , DOI: 10.1002/smll.202404685 Amith Mudugamuwa 1 , Uditha Roshan 1 , Samith Hettiarachchi 1 , Haotian Cha 1 , Hafiz Musharaf 1 , Xiaoyue Kang 1 , Quang Thang Trinh 1 , Huan Ming Xia 2 , Nam-Trung Nguyen 1 , Jun Zhang 1, 3
Affiliation
|
Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids. Periodic flows are time-dependent fluid flows, featuring repetitive patterns that can significantly improve fluid mixing and extend the effective length of microchannels for submicron and nanoparticle manipulation. Besides, periodic flow is crucial in organ-on-a-chip (OoC) for accurately modeling physiological processes, advancing disease understanding, drug development, and personalized medicine. Various techniques for generating periodic flows have been reported, including syringe pumps, peristalsis, and actuation based on electric, magnetic, acoustic, mechanical, pneumatic, and fluidic forces, yet comprehensive reviews on this topic remain limited. This paper aims to provide a comprehensive review of periodic flows in microfluidics, from fundamental mechanisms to generation techniques and applications. The challenges and future perspectives are also discussed to exploit the potential of periodic flows in microfluidics.
中文翻译：
微流体中的周期性流动
微流体技术是在微尺度通道中操纵流体的科学和技术，具有低能耗、紧凑的设备尺寸、精确控制、快速反应和增强的便携性等众多优点。这些优势导致了生物医学检测、疾病诊断、药物发现、神经科学等领域的应用。微流体通道内的流体流动通常位于层流区域，其特点是雷诺数低，但带来了流体有效混合的挑战。周期性流动是随时间变化的流体流动，具有重复模式，可以显著改善流体混合并延长亚微米和纳米颗粒操作的微通道的有效长度。此外，周期性流动在器官芯片 （OoC） 中对于准确模拟生理过程、促进疾病理解、药物开发和个性化医疗至关重要。已经报道了各种产生周期性流动的技术，包括注射泵、蠕动和基于电、磁、声、机械、气动和流体力的驱动，但关于该主题的全面综述仍然有限。本文旨在全面回顾微流体中的周期性流动，从基本机制到生成技术和应用。还讨论了挑战和未来前景，以利用微流体中周期性流动的潜力。
更新日期：2024-09-09
中文翻译：
微流体中的周期性流动
微流体技术是在微尺度通道中操纵流体的科学和技术，具有低能耗、紧凑的设备尺寸、精确控制、快速反应和增强的便携性等众多优点。这些优势导致了生物医学检测、疾病诊断、药物发现、神经科学等领域的应用。微流体通道内的流体流动通常位于层流区域，其特点是雷诺数低，但带来了流体有效混合的挑战。周期性流动是随时间变化的流体流动，具有重复模式，可以显著改善流体混合并延长亚微米和纳米颗粒操作的微通道的有效长度。此外，周期性流动在器官芯片 （OoC） 中对于准确模拟生理过程、促进疾病理解、药物开发和个性化医疗至关重要。已经报道了各种产生周期性流动的技术，包括注射泵、蠕动和基于电、磁、声、机械、气动和流体力的驱动，但关于该主题的全面综述仍然有限。本文旨在全面回顾微流体中的周期性流动，从基本机制到生成技术和应用。还讨论了挑战和未来前景，以利用微流体中周期性流动的潜力。
京公网安备 11010802027423号