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Photothermal Fish Gelatin-Graphene Microneedle Patches for Chronic Wound Treatment
Small ( IF 13.0 ) Pub Date : 2024-09-09 , DOI: 10.1002/smll.202405847 Junjie Zeng 1 , Minhui Lu 1 , Yu Wang 1, 2 , Xiaozhi Zhao 3 , Yuanjin Zhao 1, 4
Small ( IF 13.0 ) Pub Date : 2024-09-09 , DOI: 10.1002/smll.202405847 Junjie Zeng 1 , Minhui Lu 1 , Yu Wang 1, 2 , Xiaozhi Zhao 3 , Yuanjin Zhao 1, 4
Affiliation
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Microneedles are demonstrated as an effective strategy for chronic wound treatment. Great endeavors are devoted to developing microneedles with natural compositions and potent functions to promote therapeutic effects for wound healing. Herein, a novel graphene oxide-integrated methacrylated fish gelatin (GO-FGelMA) microneedle patch encapsulated with bacitracin and vascular endothelial growth factor (VEGF) is developed for chronic wound management. As the natural components and porous structures of FGelMA, the fabricated microneedle patches display satisfactory biocompatibility and drug-loading ability. Owing to the integration of graphene oxide, the microneedle patches can realize promoted drug release via near-infrared (NIR) irradiation. Besides, the encapsulated bacitracin and VEGF endow the microneedle patches with the ability to inhibit bacterial growth and promote angiogenesis. It is demonstrated that the GO-FGelMA microneedle patches with efficient drug release exert a positive influence on the wound healing process through reduced inflammation, enhanced wound closure, and improved tissue regeneration. Thus, it is believed that the proposed drugs-loaded GO-FGelMA microneedle patches will hold great potential in future chronic wound treatment.
中文翻译：
用于慢性伤口治疗的光热鱼明胶-石墨烯微针贴剂
微针被证明是治疗慢性伤口的有效策略。致力于开发具有天然成分和强大功能的微针，以促进伤口愈合的治疗效果。在此，开发了一种用杆菌肽和血管内皮生长因子 （VEGF） 封装的新型氧化石墨烯集成甲基丙烯酸鱼明胶 （GO-FGelMA） 微针贴剂，用于慢性伤口管理。作为 FGelMA 的天然成分和多孔结构，制备的微针贴剂表现出令人满意的生物相容性和载药能力。由于集成了氧化石墨烯，微针贴剂可以通过近红外 （NIR） 照射实现促进药物释放。此外，包埋的杆菌肽和 VEGF 赋予微针贴剂抑制细菌生长和促进血管生成的能力。结果表明，具有高效药物释放的 GO-FGelMA 微针贴剂通过减少炎症、增强伤口闭合和改善组织再生对伤口愈合过程产生积极影响。因此，相信所提出的载药 GO-FGelMA 微针贴剂在未来慢性伤口治疗中将具有巨大潜力。
更新日期：2024-09-09
中文翻译：
用于慢性伤口治疗的光热鱼明胶-石墨烯微针贴剂
微针被证明是治疗慢性伤口的有效策略。致力于开发具有天然成分和强大功能的微针，以促进伤口愈合的治疗效果。在此，开发了一种用杆菌肽和血管内皮生长因子 （VEGF） 封装的新型氧化石墨烯集成甲基丙烯酸鱼明胶 （GO-FGelMA） 微针贴剂，用于慢性伤口管理。作为 FGelMA 的天然成分和多孔结构，制备的微针贴剂表现出令人满意的生物相容性和载药能力。由于集成了氧化石墨烯，微针贴剂可以通过近红外 （NIR） 照射实现促进药物释放。此外，包埋的杆菌肽和 VEGF 赋予微针贴剂抑制细菌生长和促进血管生成的能力。结果表明，具有高效药物释放的 GO-FGelMA 微针贴剂通过减少炎症、增强伤口闭合和改善组织再生对伤口愈合过程产生积极影响。因此，相信所提出的载药 GO-FGelMA 微针贴剂在未来慢性伤口治疗中将具有巨大潜力。
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