Ageing is a complex multifactorial process, impacting all organs and tissues, with DNA damage accumulation serving as a common underlying cause. To decelerate ageing, various strategies have been applied to model organisms and evaluated for health and lifespan benefits. Dietary restriction (DR, also known as caloric restriction) is a well-established long-term intervention recognized for its universal anti-ageing effects. DR temporarily suppresses growth, and when applied to progeroid DNA repair-deficient mice doubles lifespan with systemic health benefits. Counterintuitively, attenuation of myostatin/activin signalling by soluble activin receptor (sActRIIB), boosts the growth of muscle and, in these animals, prevents muscle wasting, improves kidney functioning, and compresses morbidity.

中文翻译：

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通过结合饮食限制和促进 DNA 修复缺陷型早衰小鼠的肌肉生长来改善健康状况


衰老是一个复杂的多因素过程，影响所有器官和组织，DNA 损伤积累是常见的根本原因。为了延缓衰老，已经对模式生物应用了各种策略，并评估了健康和寿命的好处。饮食限制（DR，也称为热量限制）是一种公认的长期干预措施，因其普遍的抗衰老作用而得到认可。DR 暂时抑制生长，当应用于早衰 DNA 修复缺陷小鼠时，寿命延长了一倍，并具有全身健康益处。与直觉相反，可溶性激活素受体 （sActRIIB） 减弱肌肉生长抑制素/激活素信号，促进肌肉生长，在这些动物中，防止肌肉萎缩，改善肾功能，并降低发病率。