Visible-Light-Mediated Ni-Catalyzed Gas-Free Carboxylation: Stereodivergent Synthesis of E- and Z-Acrylic Acids,Organic Letters

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Visible-Light-Mediated Ni-Catalyzed Gas-Free Carboxylation: Stereodivergent Synthesis of E- and Z-Acrylic Acids
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-09 , DOI: 10.1021/acs.orglett.4c02940
Rehanguli Ruzi ₁ , Wei Shu _{1,

2}

Affiliation

Stereodivergent syntheses of different scaffolds from identical starting materials by switching the fewest parameters are among the most appealing synthetic technologies. Herein, a visible-light mediated Ni-catalyzed carboxylation of vinyl halides with formates has been developed, affording acrylic acids in both Z- and E-configurations from identical vinyl halides. The reaction features Ni-catalyzed gas-free carboxylation of vinyl halides by utilizing formates as a surrogate of carbon dioxide.

中文翻译：

可见光介导的镍催化无气羧化：E-和Z-丙烯酸的立体发散合成

通过改变最少的参数，从相同的起始材料立体发散合成不同的支架是最有吸引力的合成技术之一。在此，开发了可见光介导的卤乙烯与甲酸盐的镍催化羧化反应，由相同的卤乙烯提供Z-和E-构型的丙烯酸。该反应的特点是利用甲酸盐作为二氧化碳的替代物，进行镍催化的卤乙烯无气体羧化反应。

更新日期：2024-09-09

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