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Metabolic inflexibility of mitochondria: beneficial for the fitness of regenerating liver cells
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2024-09-09 , DOI: 10.1038/s41392-024-01959-1 Josef Ecker 1 , Sarah Brunner 1 , Klaus-Peter Janssen 2
中文翻译：
线粒体代谢不灵活：有利于肝细胞再生的健康
更新日期：2024-09-09
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2024-09-09 , DOI: 10.1038/s41392-024-01959-1 Josef Ecker 1 , Sarah Brunner 1 , Klaus-Peter Janssen 2
Affiliation
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In a recent manuscript in Science, Wang and coworkers discovered that metabolic inflexibility is required for proper mitochondrial function during liver regeneration.1 This study deepens our understanding of liver metabolism, stem cell biology and adult tissue renewal, suggesting that metabolic flexibility, generally assumed to be a selective advantage, may actually be detrimental for mitochondrial function in the regenerating liver.
中文翻译：
线粒体代谢不灵活：有利于肝细胞再生的健康
在《科学》杂志最近的一篇手稿中，王和他的同事发现，肝脏再生过程中，代谢不灵活是线粒体正常功能所必需的。 1这项研究加深了我们对肝脏代谢、干细胞生物学和成体组织更新的理解，表明代谢灵活性（通常被认为是一种选择性优势）实际上可能对再生肝脏中的线粒体功能有害。
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