Interferon disrupts immune and tissue homeostasis in SLE via CXCL13,Nature Reviews Rheumatology

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Interferon disrupts immune and tissue homeostasis in SLE via CXCL13
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2024-09-09 , DOI: 10.1038/s41584-024-01164-y
Mehrdad Pazhouhandeh ₁ , Di Yu _{1,

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Affiliation

Type I interferon has a crucial role in the immunopathogenesis of systemic lupus erythematosus (SLE). Analysis of CD4+ T cells from individuals with SLE now shows that type I interferon intervenes with the transcriptional regulators AHR and JUN to downregulate expression of IL-22, which promotes tissue regeneration, and upregulate the expression of CXCL13, which supports lymphoid structure formation.

中文翻译：

干扰素通过 CXCL13 破坏 SLE 患者的免疫和组织稳态

I 型干扰素在系统性红斑狼疮 (SLE) 的免疫发病机制中发挥着至关重要的作用。对 SLE 患者 CD4+ T 细胞的分析现在表明，I 型干扰素干扰转录调节因子 AHR 和 JUN，下调 IL-22 的表达（促进组织再生），并上调 CXCL13 的表达（支持淋巴结构形成）。

更新日期：2024-09-09

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