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Investigation of the radiosensitive properties of curcumin and temozolomide
Radiation Physics and Chemistry ( IF 2.8 ) Pub Date : 2024-09-04 , DOI: 10.1016/j.radphyschem.2024.112160
Kübra Koç , Demet Yılmaz , Elif Boydaş
Radiation Physics and Chemistry ( IF 2.8 ) Pub Date : 2024-09-04 , DOI: 10.1016/j.radphyschem.2024.112160
Kübra Koç , Demet Yılmaz , Elif Boydaş
Radiotherapy, one of the cancer treatment strategies, uses ionizing radiation to destroy cancer cells. It is very important to know the photon interaction parameters of curcumin, which has both anti-cancer and cancer-protective properties, to determine the penetration and energy accumulation in the interaction of radiation with tissue. In this work, the linear attenuation coefficient (LAC, μ ), mass attenuation coefficient (MAC, μ/ρ ), mean free path (MFP), half value layer (HVL), effective atomic number (Zeff ), and electron density (Nel ) of curcumin and temozolomide have been determined experimentally at 53.16 keV, 80.99 keV, 276.39 keV, 302.85 keV, 356.61 keV and 383.84 keV photon energies emitted from Ba133 point source by using the ULEGe detector. Besides, the radiation interaction parameters were calculated theoretically using the EpiXS software program. Also, the exposure buildup factors (EBF and EABF) of these compounds were determined up to 40 mfp in the energy range 0.015–15 MeV. The experimental and theoretical mass attenuation coefficients have been found to agree. The gamma-ray absorption efficiency of curcumin is approximately 3.89% higher than that of temozolomide. Temozolomide has approximately 25.6% higher fast neutron removal cross-section than curcumin.
中文翻译:
姜黄素和替莫唑胺的放射敏感特性研究
放射疗法是癌症治疗策略之一,它使用电离辐射来破坏癌细胞。姜黄素同时具有抗癌和防癌特性,了解姜黄素的光子相互作用参数非常重要,以确定辐射与组织相互作用中的穿透力和能量积累。本工作利用 ULEGe 探测器实验测定了姜黄素和替莫唑胺在 53.16 keV、80.99 keV、276.39 keV、302.85 keV、356.61 keV 和 383.84 keV 光子能量下姜黄素和替莫唑胺的线性衰减系数 (LAC, μ)、质量衰减系数 (MAC, μ/ρ)、平均自由程 (MFP)、半值层 (HVL)、有效原子序数 (Zeff) 和电子密度 (Nel)。此外,使用 EpiXS 软件程序对辐射相互作用参数进行理论计算。此外,在 0.015–15 MeV 的能量范围内,这些化合物的暴露积累因子(EBF 和 EABF)被测定到高达 40 mfp。实验和理论质量衰减系数是一致的。姜黄素的伽马射线吸收效率比替莫唑胺高约 3.89%。替莫唑胺的快速中子去除截面比姜黄素高约 25.6%。
更新日期:2024-09-04
中文翻译:
姜黄素和替莫唑胺的放射敏感特性研究
放射疗法是癌症治疗策略之一,它使用电离辐射来破坏癌细胞。姜黄素同时具有抗癌和防癌特性,了解姜黄素的光子相互作用参数非常重要,以确定辐射与组织相互作用中的穿透力和能量积累。本工作利用 ULEGe 探测器实验测定了姜黄素和替莫唑胺在 53.16 keV、80.99 keV、276.39 keV、302.85 keV、356.61 keV 和 383.84 keV 光子能量下姜黄素和替莫唑胺的线性衰减系数 (LAC, μ)、质量衰减系数 (MAC, μ/ρ)、平均自由程 (MFP)、半值层 (HVL)、有效原子序数 (Zeff) 和电子密度 (Nel)。此外,使用 EpiXS 软件程序对辐射相互作用参数进行理论计算。此外,在 0.015–15 MeV 的能量范围内,这些化合物的暴露积累因子(EBF 和 EABF)被测定到高达 40 mfp。实验和理论质量衰减系数是一致的。姜黄素的伽马射线吸收效率比替莫唑胺高约 3.89%。替莫唑胺的快速中子去除截面比姜黄素高约 25.6%。