. Jowitt (syn. . (L.) W. Watson var. mahapengiri. Winter) (Poaceae family) is native to tropical and semitropical areas of Asia, India, and Indonesia, and is cultivated in South and Central America. In this work, the antiproliferative potential of the essential oil of , its major compound against the HeLa cervical cancer lineage, as well as the major compound Citronellal complexed with β-cyclodextrin (β-CO) was evaluated. By gas chromatography coupled with mass spectrometry, it was possible to identify that Citronellal (38.89 %) is the major compound in . assays with cervical cancer cells (HeLa), it was possible to observe the antiproliferative activity of essential oil (CW), with IC of 1.86 μg/mL, as well as of the compound Citronellal (CO), IC 4.44 μg/mL and citronellal complexed β-cyclodextrin (β-CO), IC 2.59 μg/mL, as well as the evaluation of cell migration and cell cycle. NIH-3T3 non-tumor cells were also used to evaluate the selectivity of these compounds in tumor cells. All tested samples showed SI > 3, confirming the highest toxicity in tumor cells. All samples tested were able to decrease cell migration and when the proportion of cells in the Sub-G0 Phase was observed, all samples increased the proportion of cells with fragmented DNA, an indication of cell death, except for CW. Thus, it can be concluded that there is a potential to be explored in the essential oil, Citronellal, and Citronellal complexed with β-cyclodextrin.

中文翻译：

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综合评价香茅精油、香茅醛以及香茅醛与β-环糊精的复合物对宫颈癌细胞系（HeLa）的抗增殖作用


。 Jowitt (syn. . (L.) W. Watson var. mahapengiri. Winter)（禾本科）原产于亚洲、印度和印度尼西亚的热带和亚热带地区，在南美洲和中美洲种植。在这项工作中，评估了香茅精油的抗增殖潜力，其主要化合物针对 HeLa 宫颈癌谱系，以及主要化合物香茅醛与 β-环糊精 (β-CO) 的复合物。通过气相色谱法与质谱联用，可以确定香茅醛（38.89%）是其中的主要化合物。通过对宫颈癌细胞 (HeLa) 进行检测，可以观察到精油 (CW) 的抗增殖活性，IC 为 1.86 μg/mL，以及化合物香茅醛 (CO)，IC 为 4.44 μg/mL 和香茅醛复合 β-环糊精 (β-CO)，IC 2.59 μg/mL，以及细胞迁移和细胞周期的评估。 NIH-3T3 非肿瘤细胞也用于评估这些化合物在肿瘤细胞中的选择性。所有测试样品均显示 SI > 3，证实对肿瘤细胞的毒性最高。所有测试的样品都能够减少细胞迁移，并且当观察处于 Sub-G0 期的细胞比例时，除 CW 外，所有样品都增加了具有片段 DNA 的细胞比例，这是细胞死亡的迹象。因此，可以得出结论，精油、香茅醛以及香茅醛与β-环糊精的复合物具有开发潜力。