Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell phenotypes and spatial locations of CAFs in multiple cancer types, assess how our scheme fits within current knowledge, and invite the CAF research community to further refine it.

中文翻译：

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对癌症相关成纤维细胞进行分类——好、坏和目标


癌症相关成纤维细胞（CAF）是肿瘤微环境（TME）中普遍存在的异质基质细胞。已经描述了多种 CAF 类型，通常使用单细胞技术，例如单细胞 RNA 测序。 CAF 没有通用的分类系统，这阻碍了它们的研究和治疗靶向。我们提出了一个基于单细胞表型和多种癌症类型中 CAF 空间位置的简单 CAF 分类系统，评估我们的方案如何适应当前知识，并邀请 CAF 研究界进一步完善它。