Combination immunotherapy improves outcomes in metastatic melanoma, but the underlying mechanisms remain unclear. In this issue of Cancer Cell, Wang et al.1 report dynamics and transcriptional states of CD8+ T cell clones over time in patients treated with anti-PD-1, anti-CTLA-4, or a combination of the two. These findings have important implications for understanding and monitoring combination immunotherapy.

中文翻译：

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使用 Cyclone 轻松评估免疫治疗后 T 细胞随时间的克隆变化


联合免疫疗法可改善转移性黑色素瘤的预后，但其潜在机制仍不清楚。在本期《Cancer Cell》中，Wang 等人1 报道了接受抗 PD-1、抗 CTLA-4 或两者联合治疗的患者中 CD8+ T 细胞克隆随时间的动态和转录状态。这些发现对于理解和监测联合免疫疗法具有重要意义。