A High-Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ,Angewandte Chemie International Edition

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A High-Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-09 , DOI: 10.1002/anie.202410139
Martin Reynders ₁ , Sabine Willems ₁ , Julian A Marschner ₁ , Thomas Wein ₁ , Daniel Merk ₁ , Oliver Thorn-Seshold ₂

Affiliation

Azobenzene-based photoswitchable inverse agonists of the retinoic acid receptor-related orphan receptor γ (RORγ) enable optical control of gene expression mediated by this important nuclear hormone receptor, with excellent potency and selectivity.

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