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Solvent Minimized Synthesis of Amides by Reactive Extrusion
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-09 , DOI: 10.1002/anie.202408315 Robert R A Bolt 1 , Harry R Smallman 1 , Jamie A Leitch 1 , Gavin W Bluck 2 , Fabien Barreteau 2 , Andrei V Iosub 2 , David Constable 3 , Olivier Dapremont 4 , Paul Richardson 5 , Duncan L Browne 1
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-09 , DOI: 10.1002/anie.202408315 Robert R A Bolt 1 , Harry R Smallman 1 , Jamie A Leitch 1 , Gavin W Bluck 2 , Fabien Barreteau 2 , Andrei V Iosub 2 , David Constable 3 , Olivier Dapremont 4 , Paul Richardson 5 , Duncan L Browne 1
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The direct amidation of esters is converted from a ball-milled process into a continuous solvent-minimised reactive extrusion protocol capable of delivering 500 grams (1.3 mols) of amide product over a continuous operation for 7 hours. Key to this, was translation of heating profiles used for the ball-milling study directly to the extruder and consideration of the physical form of input substrates.
中文翻译：
反应挤出法最小化溶剂合成酰胺
酯的直接酰胺化从球磨工艺转变为连续溶剂最小化反应挤出方案，能够在连续操作 7 小时内提供 500 克（1.3 摩尔）酰胺产品。其关键是将用于球磨研究的加热曲线直接转换到挤出机并考虑输入基材的物理形式。
更新日期：2024-09-09
中文翻译：
反应挤出法最小化溶剂合成酰胺
酯的直接酰胺化从球磨工艺转变为连续溶剂最小化反应挤出方案，能够在连续操作 7 小时内提供 500 克（1.3 摩尔）酰胺产品。其关键是将用于球磨研究的加热曲线直接转换到挤出机并考虑输入基材的物理形式。
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