We propose a model for the feedback control processes that underlie the robustness and high sensitivity of mechanosensory hair cells. Our model encompasses self-tuning active processes intrinsic to these cells, which drive the amplification of mechanical stimuli by consuming metabolic energy, and a neural input process that protects these cells from damage caused by powerful stimuli. We explore the effects of these two feedback mechanisms on mechanical self-oscillations of the sense cells and their response to external forcing.

中文翻译：

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毛细胞活动过程的神经控制和先天自我调整


我们提出了一个反馈控制过程模型，该模型是机械感应毛细胞的稳健性和高灵敏度的基础。我们的模型包括这些细胞固有的自我调整活动过程，这些过程通过消耗代谢能量来驱动机械刺激的放大，以及保护这些细胞免受强大刺激造成的损害的神经输入过程。我们探讨了这两种反馈机制对感觉单元机械自振荡及其对外部强迫的响应的影响。