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RNA-binding protein SYNCRIP contributes to neuropathic pain through stabilising CCR2 expression in primary sensory neurones
British Journal of Anaesthesia ( IF 9.1 ) Pub Date : 2024-09-07 , DOI: 10.1016/j.bja.2024.07.024
Yang Zhang 1 , Bing Wang 1 , Xiaozhou Feng 1 , Huixing Wang 1 , Ju Gao 1 , Xu Li 1 , Xiaodong Huo 1 , Bushra Yasin 1 , Alex Bekker 1 , Huijuan Hu 2 , Yuan-Xiang Tao 3
Affiliation  

Nerve injury-induced changes in gene expression in the dorsal root ganglion (DRG) contribute to the genesis of neuropathic pain. SYNCRIP, an RNA-binding protein, is critical for the stabilisation of gene expression. Whether SYNCRIP participates in nerve injury-induced alterations in DRG gene expression and nociceptive hypersensitivity is unknown.

中文翻译:


RNA 结合蛋白 SYNCRIP 通过稳定初级感觉神经元中的 CCR2 表达导致神经性疼痛



神经损伤诱导的背根神经节 (DRG) 基因表达变化有助于神经性疼痛的发生。SYNCRIP 是一种 RNA 结合蛋白,对于稳定基因表达至关重要。SYNCRIP 是否参与神经损伤诱导的 DRG 基因表达改变和伤害性超敏反应尚不清楚。
更新日期:2024-09-07
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