The aryl hydrocarbon receptor is a ligand dependent transcription factor which functions as an environmental sensor. Originally discovered as the sensor for man made pollutants such as 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) it has recently gained prominence as an important mediator for environmental triggers via the diet or microbiota which influences many physiological functions in different cell types and tissues across the body. Notably AHR activity contributes to prevent excessive inflammation following tissue damage in barrier organs such as skin, lung or gut which has received wide attention in the past decade. In this review we will focus on emerging common AHR functions across cell types and tissues and discuss ongoing issues that confound the understanding of AHR physiology. Furthermore, we will discuss the need for deeper molecular understanding of the functional activity of AHR in different contexts with respect to development of potential therapeutic applications.

中文翻译：

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AHR 对免疫和组织生物学的影响。


芳烃受体是一种配体依赖性转录因子，起环境传感器的作用。它最初被发现是作为 2,3,7,8-四氯二苯并对二恶英 （TCDD） 等人造污染物的传感器，最近作为饮食或微生物群环境触发因素的重要介质而受到重视，它影响着身体不同细胞类型和组织的许多生理功能。值得注意的是，AHR 活性有助于防止皮肤、肺或肠道等屏障器官组织损伤后过度炎症，这在过去十年中受到了广泛关注。在这篇综述中，我们将重点介绍跨细胞类型和组织出现的常见 AHR 功能，并讨论混淆对 AHR 生理学理解的持续问题。此外，我们将讨论在不同情况下对 AHR 的功能活性进行更深入的分子理解的必要性，以开发潜在的治疗应用。