Prenatal exposure to organophosphorus flame retardants (OPFRs) has been linked with adverse effects on reproductive health, and new OPFRs are continually emerging. In this study, emerging OPFRs, such as bis(2-ethylhexyl) phenyl phosphate (BEHPP), triamyl phosphate (TAP), tris(4-tert-butylphenyl) phosphate (T4tBPPP), oxydi-2,1-ethanediyl phosphoric acid tetrakis(2 chloro-1-methylethyl) ester (RDT905), cresyl diphenyl phosphate (CDP), and 2-isopropylphenyl diphenyl phosphate (2IPPDPP), were detected in 84 %, 100 %, 100 %, 52 %, 40 %, and 40 % of 25 decidua samples with average concentrations of 2.36, 6.21, 1.5, 2.6, 1.07, and 0.09 ng/g of dry weight (dw), respectively. Six of the aforementioned emerging OPFRs (BEHPP, T4tBPPP, RDT905, 2IPPDPP, CDP, and TAP) were simultaneously detected in paired chorionic villus samples, and their average concentrations were 11.3, 1.77, 3.64, 0.11, 0.58, and 3.34 ng/g, which were significantly higher than and positively correlated with those in decidua samples. The geometric mean concentration ratios between chorionic villus and decidua samples for BEHPP, T4tBPPP, RDT905, 2IPPDPP, CDP, and TAP were 4.02, 1.61, 1.73, 1.48, 0.82, and 0.69, respectively, consistent with transthyretin binding-dependent behavior. Prenatal exposure to such emerging OPFRs, especially for BEHPP with relatively high concentration and maternal transfer, is of high concern from the view of women’s reproductive health.

中文翻译：

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新兴有机磷酸酯阻燃剂 (OPFR) 在孕妇中的暴露水平和母体转移：与传统 OPFR 的比较


产前接触有机磷阻燃剂 (OPFR) 会对生殖健康产生不利影响，并且新的 OPFR 不断出现。在这项研究中，新兴的OPFR，例如磷酸双(2-乙基己基)苯基酯(BEHPP)、磷酸三戊酯(TAP)、磷酸三(4-叔丁基苯基)酯(T4tBPPP)、氧化二-2,1-乙二基磷酸四酯(2 氯-1-甲基乙基)酯 (RDT905)、磷酸甲苯二苯酯 (CDP) 和磷酸 2-异丙基苯基二苯酯 (2IPPDPP) 在 84 %、100 %、100 %、52 %、40 % 和 40 % 中检测到25 个蜕膜样品的百分比，平均浓度分别为 2.36、6.21、1.5、2.6、1.07 和 0.09 ng/g 干重 (dw)。在配对的绒毛膜绒毛样本中同时检测到上述六种新兴OPFR（BEHPP、T4tBPPP、RDT905、2IPPDPP、CDP和TAP），其平均浓度分别为11.3、1.77、3.64、0.11、0.58和3.34 ng/g。显着高于蜕膜样本，且与蜕膜样本呈正相关。 BEHPP、T4tBPPP、RDT905、2IPPDPP、CDP 和 TAP 的绒毛膜绒毛和蜕膜样品之间的几何平均浓度比分别为 4.02、1.61、1.73、1.48、0.82 和 0.69，与转甲状腺素蛋白结合依赖性行为一致。从妇女生殖健康的角度来看，产前接触此类新出现的 OPFRs，特别是相对较高浓度的 BEHPP 和母体转移，值得高度关注。