Aims Circulating dimethylguanidino valeric acid (DMGV) was identified as a novel metabolite related to cardiorespiratory fitness and cardiometabolic abnormalities. Circulating DMGV levels are subjective to dietary modulation; however, studies on its associations with intakes of coronary heart disease (CHD)–related foods/nutrients are limited. We investigated whether plasma DMGV was related to risk of incident CHD. We tested associations of DMGV with CHD-related dietary intakes measured by 7-day dietary records and estimated corresponding disease risk. Methods and results This nested case–control study on the incidence of CHD included 1520 women (760 incident cases of fatal CHD and nonfatal myocardial infarction and 760 controls) from the Nurses’ Health Study. Separately, plasma DMGV and CHD-related dietary intakes and cardiometabolic abnormalities were assessed in the Women’s Lifestyle Validation Study (WLVS; n = 724). Higher plasma DMGV was related to a greater risk of CHD [relative risk (RR) per 1 SD, 1.26 (95% CI 1.13, 1.40); P-for-linearity = 0.006]. Greater intakes of sodium, energy-dense foods, and processed/red meat were related to higher DMGV levels; every 1 SD intake of sodium was associated with β 0.13 (SE 0.05; P = 0.007) for DMGV Z-scores, which corresponded to a RR of 1.031 (1.016, 1.046) for CHD. High DMGV (the top quartile, Q4) showed a significant RR of 1.60 (1.17, 2.18) after adjusting for diet and lifestyle factors; the RR further adjusting for obesity and hypertension was 1.29 (0.93, 1.79) as compared with the lowest quartile. In both cohorts, greater adiposity and adverse cardiometabolic factor status were significantly related to higher DMGV levels. Conclusion Higher levels of plasma DMGV, a metabolite reflecting unfavourable CHD-related dietary intakes, were associated with an increased risk of CHD. The unfavourable association was attenuated by cardiometabolic risk factor status. Our study underscores the potential importance of plasma DMGV as an early biomarker associated with diet and the long-term risk of CHD among women.

中文翻译：

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循环中二甲基胍基戊酸、饮食因素和冠心病风险


目的 循环二甲基胍基戊酸 （DMGV） 被确定为一种与心肺健康和心脏代谢异常相关的新型代谢物。循环 DMGV 水平对饮食调节有主观影响;然而，关于其与冠心病 （CHD） 相关食物/营养素摄入量相关的研究有限。我们调查了血浆 DMGV 是否与发生 CHD 的风险有关。我们测试了 DMGV 与 CHD 相关饮食摄入量的关联，并通过 7 天饮食记录测量并估计了相应的疾病风险。方法和结果这项关于 CHD 发病率的嵌套病例对照研究包括来自护士健康研究的 1520 名女性 （760 例致死性 CHD 和非致死性心肌梗死的发病病例和 760 例对照）。另外，在女性生活方式验证研究 （WLVS; n = 724） 中评估了血浆 DMGV 和 CHD 相关的膳食摄入量和心脏代谢异常。较高的血浆 DMGV 与较高的 CHD 风险相关 [每 1 SD 的相对风险 （RR），1.26 （95% CI 1.13,1.40）;线性度 P = 0.006]。钠、能量密集型食物和加工/红肉摄入量的增加与较高的 DMGV 水平有关;每 1 SD 钠摄入量与 β 0.13 相关 （SE 0.05;DMGV Z 评分的 P = 0.007），对应于 CHD 的 RR 为 1.031 （1.016， 1.046）。高 DMGV（前四分位数，第 4 季度）在调整饮食和生活方式因素后显示显著的 RR 为 1.60 （1.17， 2.18）;与最低四分位数相比，进一步调整肥胖和高血压的 RR 为 1.29 （0.93， 1.79）。在这两个队列中，较高的肥胖和不良的心脏代谢因子状态与较高的 DMGV 水平显著相关。 结论 血浆 DMGV 水平较高（一种反映 CHD 相关膳食摄入不利的代谢物）与 CHD 风险增加相关。心脏代谢危险因素状态减弱了这种不利关联。我们的研究强调了血浆 DMGV 作为与饮食相关的早期生物标志物的潜在重要性以及女性患 CHD 的长期风险。