Individual Difference in the Capacity of Gut Microbiota to Ferment Four Complex Carbohydrates from Normal to Overweight People: An In Vitro Study,Journal of Agricultural and Food Chemistry

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Individual Difference in the Capacity of Gut Microbiota to Ferment Four Complex Carbohydrates from Normal to Overweight People: An In Vitro Study
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-06 , DOI: 10.1021/acs.jafc.4c05864
Chengxiao Yu ₁ , Shokouh Ahmadi ₁ , Xinxin Hu ₁ , Jiaxiong Wu ₁ , Dongmei Wu ₁ , Zhiqiang Hou ₁ , Haibo Pan _{1,

2} , Hang Xiao ₁ , Xingqian Ye _{1,

2,

3,

4} , Shiguo Chen _{1,

2,

3,

4}

Affiliation

Pectic polysaccharides can beneficially shape the human microbiota. However, individual variability in the microbial response, especially the response between normal-weight (NW) and overweight (OW) people, is rarely understood. Therefore, we performed batch fermentation using inulin (INU), commercial pectin (CP), and pectic polysaccharides extracted from goji berry (GPP) and raspberry (RPP) by microbiota from five normal-weight (NW) and five overweight (OW) donors. The degree of specificity of fiber was negatively correlated to its fermentable rate and microbial response. Meanwhile, we found that microbiota from OW donors had a stronger fiber-degrading capacity than NW donors. The result of correlation between individual basal microbiota and the fermentable rate indicated Dialister, Megamonas, Oscillospiraceae_NK4A214, Prevotella, Ruminococcus, and unidentified_Muribaculaceae may be the key bacteria. In summary, we highlighted a new perspective regarding the interactive relationship between different fibers and fecal microbiota from different donors that may be helpful to design fiber interventions for individuals with different microbiota.

中文翻译：

正常人和超重人群肠道微生物群发酵四种复杂碳水化合物的能力存在个体差异：一项体外研究

果胶多糖可以有益地塑造人体微生物群。然而，微生物反应的个体差异，尤其是正常体重（NW）和超重（OW）人群之间的反应，却很少被了解。因此，我们使用从枸杞子 (GPP) 和覆盆子 (RPP) 中提取的菊粉 (INU)、商业果胶 (CP) 和果胶多糖，通过五个正常体重 (NW) 和五个超重 (OW) 供体的微生物群进行分批发酵。。纤维的特异性程度与其可发酵率和微生物反应呈负相关。同时，我们发现来自 OW 供体的微生物群比 NW 供体具有更强的纤维降解能力。个体基础菌群与发酵率的相关性结果表明， Dialister 、 Megamonas 、 Oscillospiraceae_NK4A214 、 Prevotella 、 Ruminococcus和unidentified_Muribaculaceae可能是关键细菌。总之，我们强调了关于不同纤维与来自不同捐赠者的粪便微生物群之间相互作用关系的新观点，这可能有助于为具有不同微生物群的个体设计纤维干预措施。

更新日期：2024-09-06

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