Innovative Applications of Pectin in Lipid Management: Mechanisms, Modifications, Synergies, Nanocarrier Systems, and Safety Considerations,Journal of Agricultural and Food Chemistry

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Innovative Applications of Pectin in Lipid Management: Mechanisms, Modifications, Synergies, Nanocarrier Systems, and Safety Considerations
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-06 , DOI: 10.1021/acs.jafc.4c06586
Haizhao Song ₁ , Fangmin Chen ₁ , Yubo Cao ₁ , Fang Wang ₁ , Luanfeng Wang ₁ , Ling Xiong ₁ , Xinchun Shen ₁

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Pectin, a natural polysaccharide predominantly sourced from the cell walls of terrestrial plants, is widely regarded for its gelling, thickening, and stabilizing properties, which have extensive applications in the food, pharmaceutical, and biotechnological industries. This review discusses the mechanistic pathways by which pectin mediates its lipid-lowering properties, such as pectin’s antioxidant activity, the modulation of gut microbiota, its anti-inflammatory properties, its capacity to bind bile acids and cholesterol, and its impact on the expression of genes associated with lipid metabolism. To enhance its hypolipidemic properties, chemical, physical, and enzymatic modification techniques are explored. Additionally, the synergistic effects of pectin in combination with other bioactive compounds such as phytosterols and polyphenols, as well as its potential in nanocarrier-mediated delivery systems for lipid-lowering agents, are highlighted. The review also conducts a critical analysis of the safety and regulatory considerations associated with pectin use, emphasizing the necessity for comprehensive toxicological evaluations and adherence to regulatory standards. This paper underscores the growing potential of pectin not only as a dietary fiber but also as a multifaceted agent for ameliorating hyperlipidemia, catalyzing a shift toward more targeted and efficacious lipid-lowering strategies.

中文翻译：

果胶在脂质管理中的创新应用：机制、修饰、协同作用、纳米载体系统和安全考虑

果胶是一种主要来源于陆地植物细胞壁的天然多糖，因其胶凝、增稠和稳定特性而被广泛认为，在食品、制药和生物技术行业有着广泛的应用。本综述讨论了果胶介导其降脂特性的机制途径，例如果胶的抗氧化活性、肠道微生物群的调节、其抗炎特性、其结合胆汁酸和胆固醇的能力以及其对表达的影响与脂质代谢相关的基因。为了增强其降血脂特性，人们探索了化学、物理和酶改性技术。此外，还强调了果胶与其他生物活性化合物（如植物甾醇和多酚）结合的协同效应，及其在纳米载体介导的降脂剂递送系统中的潜力。该审查还对与果胶使用相关的安全性和监管考虑因素进行了批判性分析，强调了全面毒理学评估和遵守监管标准的必要性。本文强调，果胶不仅作为膳食纤维，而且作为改善高脂血症的多方面药物，其潜力不断增长，从而促进向更有针对性和更有效的降脂策略的转变。

更新日期：2024-09-06

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