Marine microorganisms like Tistrella are essential for producing bioactive compounds, including didemnins with antitumor and antiviral properties. However, our understanding of Tistrella's ecological features and didemnin production in natural environments is limited. In this study, we used genomics and metagenomics to show that Tistrella is widely distributed across natural habitats, especially in marine environments from the surface to 5000 m deep, with distinct non-random distribution patterns revealed by co-occurrence analysis. Importantly, transcriptional profiling of didemnin biosynthetic gene clusters indicates active in situ production of this compound within marine ecosystems. These findings enhance our understanding of Tistrella's ecology and secondary metabolite production in natural environments. Further research is needed to explore the ecological dynamics and functional impacts of Tistrella in these ecosystems.

中文翻译：

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全球微生物组分析揭示了 Tistrella 的生态特征及其在海洋生态系统中产生的生物活性迪德宁


像 Tistrella 这样的海洋微生物对于生产生物活性化合物至关重要，其中包括具有抗肿瘤和抗病毒特性的双孢宁。然而，我们对 Tistrella 的生态特征和自然环境中的去甲宁生产的了解是有限的。在这项研究中，我们利用基因组学和宏基因组学表明，Tistrella广泛分布于自然栖息地，尤其是从表面到5000米深的海洋环境中，共现分析揭示了独特的非随机分布模式。重要的是，didemnin 生物合成基因簇的转录谱表明该化合物在海洋生态系统中的原位生产活跃。这些发现增强了我们对 Tistrella 生态学和自然环境中次生代谢产物产生的理解。需要进一步研究来探索 Tistrella 在这些生态系统中的生态动态和功能影响。