The long-term objective of tandem reaction is to investigate ‘intelligent’ tandem reaction systems akin to living cells. Here we’ve prepared an ‘intelligent’ droplet microreactor for the tandem reaction using droplet microfluidic technology constructing a photoresponsive microfluidic tandem reaction system. The method leverages a three-phase emulsion’s ‘two membranes and three phases’ structure to segregate incompatible reagents, and introduces a stimulating surfactant to control the structure of this emulsion structure for intelligent reaction sequence control, enablingefficient,orderlytandem reactionwithin the same system. Validating this concept, we applied the droplet microreactor to the condensation-reduction cascade reaction, as envisioned, incompatible condensation and reduction reactions, were coordinated by cycling the UV light on /off for a smooth cascade reaction. Compared to batch reaction, the droplet microreactor showed sixfold catalytic efficiency enhancement and > 99 % reaction selectivity. Our work offers novel insights into realizing intelligent cascade reactions.

中文翻译：

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用于串联反应的光响应微流体三相乳液


串联反应的长期目标是研究类似于活细胞的“智能”串联反应系统。在这里，我们准备了一个用于串联反应的“智能”液滴微反应器，使用液滴微流控技术构建了一个光响应微流控串联反应系统。该方法利用三相乳液的“两膜三相”结构来分离不相容的试剂，并引入刺激性表面活性剂来控制这种乳液结构的结构，以实现智能反应序列控制，从而在同一系统内实现高效、有序的串联反应。为了验证这一概念，我们将液滴微反应器应用于缩合-还原级联反应，正如设想的那样，不相容的缩合和还原反应通过循环打开/关闭紫外光来实现平稳的级联反应。与间歇反应相比，液滴微反应器的催化效率提高了 6 倍，> 的反应选择性为 99%。我们的工作为实现智能级联反应提供了新的见解。