Detecting endocrine-disrupting phenolic substances like bisphenol A (BPA) and bisphenol S (BPS) in food products due to leakage from plastic packaging is crucial due to their potential health hazards such as hormonal disruption, metabolic disorders, cancer etc. Despite a wide range of bimetallic and trimetallic MOF-based structures have been developed for the sensitive detection of these pollutants; however, achieving a highly selective and sensitive hybrid system with diverse and effective binding sites for simultaneous and selective monitoring of these pollutants remains challenging. To address this, herein we developed a novel electrode system using thiourea functionalized trimetallic (Fe, Co, and Mn) organic framework (S-FCM-MOF) coated polycaprolactone (PCL) electrospun nanofibers. Interestingly, the S-functionalization enhances adsorption capacity for BPA and BPS, whereas PCL improves electrical conductivity and charge density across the FCM-MOF-based electrode surface, thus overcoming the challenge of achieving a highly selective and sensitive hybrid system for the simultaneous and precise detection of these pollutants. This synergistic effect leads to high sensitivity (7.0479, 5.9249 μA/μM/cm²), low detection limits (2.57, 2.91 μM), and wide linear ranges (5–365, 5–360 μM) against BPA and BPS, respectively. Furthermore, the S-FCM-MOF@PCL electrode demonstrates high selectivity for BPA and BPS even in presence of interfering species including Mg²⁺, Zn²⁺, Cu²⁺, NO₃⁻, KCl, AA, CA, HQ, PNP, KBr and MgSO₄. This innovative designed electrode is effectively used for sensitive/selective monitoring of BPA and BPS from plastic bag-packaged frozen meat samples with high precision and accuracy, thus ensuring the reliability of our designed sensor.

中文翻译：

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使用三金属 MOF 涂层的静电纺丝纳米纤维灵敏检测塑料包装冷冻肉中的双酚 A 和 S


由于塑料包装泄漏而检测食品中双酚 A （BPA） 和双酚 S （BPS） 等干扰内分泌的酚类物质至关重要，因为它们具有潜在的健康危害，例如荷尔蒙紊乱、代谢紊乱、癌症等。尽管双金属和三金属结构范围很广，但已经开发了基于 MOF 的结构来灵敏地检测这些污染物;然而，实现具有多种有效结合位点的高选择性和灵敏杂交系统，以同时和选择性地监测这些污染物仍然具有挑战性。为了解决这个问题，我们在这里开发了一种新型电极系统，使用硫脲功能化三金属（Fe、Co 和 Mn）有机框架 （S-FCM-MOF） 涂层的聚己内酯 （PCL） 静电纺丝纳米纤维。有趣的是，S 官能团化增强了对 BPA 和 BPS 的吸附能力，而 PCL 提高了基于 FCM-MOF 的电极表面的电导率和电荷密度，从而克服了实现高选择性和灵敏混合系统以同步和精确检测这些污染物的挑战。这种协同效应分别导致对 BPA 和 BPS 的高灵敏度（7.0479、5.9249 μA/μM/cm²）、低检测限（2.57、2.91 μM）和宽线性范围（5-365、5-360 μM）。此外，S-FCM-MOF@PCL电极对 BPA 和 BPS 表现出高选择性，即使存在包括 Mg²⁺、Zn²⁺、Cu²⁺、NO₃⁻、KCl、AA、CA、HQ、PNP、KBr 和 MgSO₄ 在内的干扰物质。这种创新设计的电极可有效用于灵敏/选择性监测塑料袋包装的冷冻肉类样品中的 BPA 和 BPS，具有高精度和准确度，从而确保我们设计的传感器的可靠性。