Simulation of the dynamic behavior of mitral valve closure could improve clinical treatment by predicting surgical procedures outcome. We propose here a method to achieve this goal by using the immersed boundary method. In order to go towards patient-based simulation, we tailor our method to be adapted to a valve extracted from medical image data. It includes investigating segmentation process, smoothness of geometry, case setup and the shape of the left ventricle. We also study the influence of leaflet tissue anisotropy on the quality of the valve closure by comparing with an isotropic model. As part of the anisotropy analysis, we study the influence of the principal material direction by comparing methods to obtain them without dissection.

中文翻译：

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基于图像的二尖瓣动态闭合模拟，包括各向异性


二尖瓣关闭动态行为的模拟可以通过预测手术结果来改善临床治疗。我们在这里提出一种使用浸入边界法来实现这一目标的方法。为了实现基于患者的模拟，我们定制了我们的方法以适应从医学图像数据中提取的阀门。它包括研究分割过程、几何形状的平滑度、病例设置和左心室的形状。我们还通过与各向同性模型进行比较，研究了瓣叶组织各向异性对瓣膜闭合质量的影响。作为各向异性分析的一部分，我们通过比较无需解剖即可获得主材料方向的方法来研究主材料方向的影响。