Electrospinning is a unique technology based on the fabrication of polymer fibers from the solution under an applied electric field. Electrospun membranes are applied in various fields, starting from filter technologies to tissue engineering. Polyalyletherketones (PAEK) is a family of synthetic bioinert polymers characterized by outstanding mechanical performance, high chemical stability, and biocompatibility. In the present study, the effect of electrospinning parameters (collector-to-tip distance, applied voltage, spinning solution flow rate and polymer concentration in the spinning solution) on the morphology of the fabricated polyetherketoneketone (PEKK) membranes as well as their crystal structure, chemical stability and biocompatibility was investigated. Based on 108 combinations of the electrospinning parameters, it was found that minimum concentration of PEKK in the spinning solution in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFP) required for the fibers’ formation is 4 wt %, while the applied voltage providing fibers without defects was found at 20 kV. It was demonstrated that the tested electrospinning regimes allow to fabricate the membranes with average fiber diameter from 0.76 ± 0.29 to 1.46 ± 0.60 μm and porosity from 87 ± 1 to 92 ± 1 %. It was found that electrospinning process has no effect on the chemical structure of PEKK macromolecules. Electrospinning parameters had no effect on crystal structure of PEKK in the fabricated membranes, which was found to be amorphous. The fabricated membranes demonstrated high Young modulus (above 150 MPa) and elongation over 170 %, were stable in strong alkali and acid solutions and biocompatible towards mouse embryonic fibroblasts.

中文翻译：

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聚醚酮酮纤维的静电纺丝：制备工艺对形态、物理化学和生物学特性的影响


静电纺丝是一种独特的技术，基于在施加的电场下从溶液中制造聚合物纤维。静电纺丝膜应用于从过滤技术到组织工程的各个领域。聚芳醚酮 (PAEK) 是一类合成生物惰性聚合物，具有出色的机械性能、高化学稳定性和生物相容性。在本研究中，静电纺丝参数（收集器到尖端的距离、施加电压、纺丝溶液流速和纺丝溶液中的聚合物浓度）对所制备的聚醚酮酮（PEKK）膜的形态及其晶体结构的影响，研究了化学稳定性和生物相容性。基于 108 种静电纺丝参数组合，发现纺丝溶液中 1,1,1,3,3,3-六氟丙-2-醇 (HFP) 中 PEKK 形成纤维所需的最低浓度为 4 wt%，而提供没有缺陷的纤维的施加电压被发现为20kV。结果表明，测试的静电纺丝方案可以制造平均纤维直径为 0.76 ± 0.29 至 1.46 ± 0.60 μm、孔隙率为 87 ± 1 至 92 ± 1% 的膜。结果发现静电纺丝过程对PEKK大分子的化学结构没有影响。静电纺丝参数对制备的膜中 PEKK 的晶体结构没有影响，发现它是无定形的。制备的膜具有高杨氏模量（高于150 MPa）和超过170%的伸长率，在强碱和强酸溶液中稳定，并且与小鼠胚胎成纤维细胞具有生物相容性。