Apoptotic bodies play an important role in the cellular communication as a consequence of the great variety of biomolecules they harbor. There is evidence that 1st generation apoptotic bodies from HK-2 cells induced by cisplatin or UV light trigger apoptosis in naïve HK-2 cells whereas 2nd generation apoptotic bodies activate cell proliferation showing an opposite effect. Thus, the development of new analytical strategies to quantify the changes in the involved metabolites is imperative to shed light on the biological mechanisms which trigger apoptosis and cell proliferation.

中文翻译：

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通过基于液相色谱-串联质谱的靶向代谢组学定量 HK-2 细胞凋亡小体中的相关代谢物


凋亡小体在细胞通讯中起着重要作用，因为它们含有多种生物分子。有证据表明，顺铂或紫外线诱导的 HK-2 细胞的第一代凋亡小体会触发幼稚 HK-2 细胞的凋亡，而第二代凋亡小体会激活细胞增殖，显示出相反的效果。因此，开发新的分析策略来量化相关代谢物的变化对于阐明触发细胞凋亡和细胞增殖的生物学机制至关重要。