An Approach to Apply BDNF Targeting Fe3O4-Based Nanoparticles as Multifunctional Anti-Alzheimer Agents,Small

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An Approach to Apply BDNF Targeting Fe3O4-Based Nanoparticles as Multifunctional Anti-Alzheimer Agents
Small ( IF 13.0 ) Pub Date : 2024-09-06 , DOI: 10.1002/smll.202403625
Lei Fang ₁ , Yunxia Song ₁ , Haifeng Jin ₁ , Yinyin Liu ₂ , Shaohua Gou ₁

Affiliation

To search for novel anti-Alzheimer agents, multifunctional Fe₃O₄-based nanoparticles (FSSIO) is designed and prepared which contain ferulic acid (FA) and Simvastatin linked to the surface of Fe₃O₄ particles. In vitro tests confirmed that FSSIO possessed favorable biocompatibility and a pronounced ability to penetrate blood brain barrier. The FA moiety endowed the particles with remarkable antioxidant and anti-inflammatory properties, and effectively protected neuron cells from the toxicity induced by Aβ. Moreover, the Simvastatin pharmacophore assists the particles up-regulate the expression level of BDNF and significantly promotes the expression levels of p-TrkB, p-ERK, p-PI3K and Akt, which consequently leads to the neurite outgrowth via regulating PI3K/ATK and TrkB-mediated signaling pathway. More importantly, in the Morris water maze test, FSSIO shows excellent activity to enhance the learning and memory retention of AD model rats.

中文翻译：

一种将靶向 Fe3O4 基纳米颗粒的 BDNF 用作多功能抗阿尔茨海默病剂的方法

为了寻找新型抗阿尔茨海默病药物，设计并制备了多功能 Fe₃O₄ 基纳米颗粒（FSSIO），其中含有与 Fe₃O₄ 颗粒表面相连的阿魏酸（FA）和辛伐他汀。体外试验证实，FSSIO 具有良好的生物相容性和穿透血脑屏障的显着能力。FA 部分赋予颗粒显着的抗氧化和抗炎特性，并有效保护神经元细胞免受 Aβ 诱导的毒性。此外，辛伐他汀药效团协助颗粒上调 BDNF 的表达水平，并显着促进 p-TrkB 、 p-ERK 、 p-PI3K 和 Akt 的表达水平，从而通过调节 PI3K/ATK 和 TrkB 介导的信号通路导致神经突生长。更重要的是，在 Morris 水迷宫测试中，FSSIO 显示出增强 AD 模型大鼠学习和记忆保留的出色活性。

更新日期：2024-09-06

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