Higher accelerometer-assessed volume and intensity of physical activity (PA) have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA. We aimed to: (a) improve interpretability by producing UK Biobank age-referenced centiles for PA volume and intensity; (b) inform public-health messaging by examining how adding recommended quantities of moderate and vigorous PA affect PA volume and intensity. 92,480 UK Biobank participants aged 43–80 years with wrist-worn accelerometer data were included. Average acceleration and intensity gradient were derived as proxies for PA volume and intensity. We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape (GAMLSS) and modeled the effect of adding moderate (walking) or vigorous (running) activity on the combined change in the volume and intensity centiles (change in PA profile). In men, volume was lower as age increased while intensity was lower after age 55; in women, both volume and intensity were lower as age increased. Adding 150 min of moderate PA weekly (5 × 30 min walking) increased the PA profile by 4 percentage points. Defining moderate PA as brisk walking approximately doubled the increase (9 percentage points) while 75 min of vigorous PA weekly (5 × 15 min running) trebled the increase (13 percentage points). These UK Biobank reference centiles provide a benchmark for interpretation of accelerometer data. Application of our translational methods demonstrate that meeting PA guidelines through shorter duration vigorous activity is more beneficial to the PA profile (volume and intensity) than longer duration moderate activity.

中文翻译：

---

根据英国生物银行数据，通过年龄参考值加强对加速计评估的身体活动的临床和公共卫生解释


加速度计评估的体力活动 (PA) 量和强度越高，预期寿命越长，但很难转化为推荐的 PA 剂量。我们的目标是：(a) 通过生成英国生物银行年龄参考的 PA 体积和强度百分位来提高可解释性； (b) 通过检查添加推荐量的中度和强力 PA 如何影响 PA 量和强度，为公共卫生信息提供信息。纳入了 92,480 名年龄在 43-80 岁的英国生物银行参与者，他们拥有腕戴式加速度计数据。得出平均加速度和强度梯度作为 PA 体积和强度的代表。我们使用位置尺度和形状的广义加性模型 (GAMLSS) 生成了性别特异性百分位数曲线，并模拟了添加中等（步行）或剧烈（跑步）活动对体积和强度百分位数综合变化（PA 分布变化）的影响）。对于男性来说，随着年龄的增长，训练量会降低，而 55 岁以后强度会降低；对于女性来说，随着年龄的增长，训练量和强度都会降低。每周增加 150 分钟的适度 PA（步行 5 × 30 分钟）可将 PA 曲线提高 4 个百分点。将中度 PA 定义为快走，大约会使增加一倍（9 个百分点），而每周 75 分钟的剧烈 PA（跑步 5 × 15 分钟）会使增加增加三倍（13 个百分点）。这些英国生物银行参考百分位数为加速计数据的解释提供了基准。我们的转化方法的应用表明，通过较短持续时间的剧烈活动来满足 PA 指南比较长持续时间的中等活动更有利于 PA 曲线（体积和强度）。