Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial,The Lancet Gastroenterology & Hepatology

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Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial
The Lancet Gastroenterology & Hepatology ( IF 30.9 ) Pub Date : 2024-09-02 , DOI: 10.1016/s2468-1253(24)00200-0
Matthew C Choy ₁ , Christopher F D Li Wai Suen ₁ , Danny Con ₁ , Kristy Boyd ₂ , Raquel Pena ₂ , Kathryn Burrell ₂ , Ourania Rosella ₂ , David Proud ₃ , Richard Brouwer ₃ , Alexandra Gorelik ₄ , Danny Liew ₅ , William R Connell ₆ , Emily K Wright ₆ , Kirstin M Taylor ₇ , Aviv Pudipeddi ₈ , Michelle Sawers ₉ , Britt Christensen ₁₀ , Watson Ng ₁₁ , Jakob Begun ₁₂ , Graham Radford-Smith ₁₃ , Mayur Garg ₁₄ , Neal Martin ₁₅ , Daniel R van Langenberg ₁₆ , Nik S Ding ₆ , Lauren Beswick ₉ , Rupert W Leong ₈ , Miles P Sparrow ₇ , Peter De Cruz ₁

Affiliation

Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia.
Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.
Department of Colorectal Surgery, Austin Health, Melbourne, VIC, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Department of Medicine, University of Adelaide, Adelaide, SA, Australia.
Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.
Department of Gastroenterology, Alfred Health and Monash University, Melbourne, VIC, Australia.
Department of Gastroenterology Concord Repatriation General Hospital, Sydney, NSW, Australia.
Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia.
Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia.
Department of Gastroenterology, Mater Hospital, Brisbane, QLD, Australia.
Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Gastroenterology, Northern Health, Melbourne, VIC, Australia.
Department of Gastroenterology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Department of Gastroenterology, Eastern Health, Melbourne, VIC, Australia.

The optimal dosing strategy for infliximab in steroid-refractory acute severe ulcerative colitis (ASUC) is unknown. We compared intensified and standard dose infliximab rescue strategies and explored maintenance therapies following infliximab induction in ASUC.

中文翻译：

类固醇难治性急性严重溃疡性结肠炎（PREDICT-UC）的强化与标准剂量英夫利昔单抗诱导治疗：一项开放标签、多中心、随机对照试验

英夫利昔单抗治疗类固醇难治性急性严重溃疡性结肠炎（ASUC）的最佳给药策略尚不清楚。我们比较了强化剂量和标准剂量英夫利昔单抗挽救策略，并探讨了 ASUC 英夫利昔单抗诱导后的维持治疗。

更新日期：2024-09-02

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