Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop resistance mechanisms against a variety of clinically relevant antibiotics. In this comprehensive review, we carefully dissect the resistance mechanisms employed by S. aureus against various antibiotics commonly used in clinical settings. The article navigates through intricate molecular pathways, elucidating the mechanisms by which S. aureus evades the therapeutic efficacy of antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, etc. Each antibiotic is scrutinised for its mechanism of action, impact on bacterial physiology, and the corresponding resistance strategies adopted by S. aureus. By synthesising the knowledge surrounding these resistance mechanisms, this review aims to serve as a comprehensive resource that provides a foundation for the development of innovative therapeutic strategies and alternative treatments for S. aureus infections. Understanding the evolving landscape of antibiotic resistance is imperative for devising effective countermeasures in the battle against this formidable pathogen.

中文翻译：

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葡萄球菌对临床相关抗生素耐药的机制


金黄色葡萄球菌是一种臭名昭著的病原体，具有多种毒力，由于其能够对各种临床相关抗生素产生耐药机制，因此对当前的抗生素治疗构成了重大挑战。在这篇全面的综述中，我们仔细剖析了金黄色葡萄球菌对临床环境中常用的各种抗生素的耐药机制。本文通过错综复杂的分子途径，阐明了金黄色葡萄球菌逃避抗生素（如 β-内酰胺类、万古霉素、达托霉素、利奈唑胺等）治疗效果的机制。每种抗生素的作用机制、对细菌生理学的影响以及金黄色葡萄球菌采用的相应耐药策略都经过仔细检查。通过综合围绕这些耐药机制的知识，本综述旨在作为一种综合资源，为开发金黄色葡萄球菌感染的创新治疗策略和替代疗法提供基础。了解抗生素耐药性不断变化的形势对于制定对抗这种强大病原体的有效对策至关重要。