Tetrahydroberberine Prevents Ovariectomy-Induced Bone Loss by Inhibiting RANKL-Induced Osteoclastogenesis and Promoting Osteoclast Apoptosis,Journal of Agricultural and Food Chemistry

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Tetrahydroberberine Prevents Ovariectomy-Induced Bone Loss by Inhibiting RANKL-Induced Osteoclastogenesis and Promoting Osteoclast Apoptosis
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-05 , DOI: 10.1021/acs.jafc.4c02982
Qihang Wu ₁ , Haibo Liang ₁ , Chenyu Wang ₂ , Yiqi Chen ₂ , Chenxin Yu ₃ , Jiangtao Luo ₁ , Luqiong Cai ₃ , Jiansen Miao ₁ , Jiake Xu _{1,

4} , Haiming Jin ₁ , Xiangyang Wang ₁

Affiliation

Postmenopausal osteoporosis (PMOP) arises from the disruption in bone remodeling caused by estrogen deficiency, leading to a heightened susceptibility to osteoporotic fractures in aging women. Tetrahydroberberine (THB) is a chemical compound extracted from Corydalis yanhusuo, a member of the traditional Chinese medicine series “Zhejiang eight taste”, possessing a variety of pharmacological functions such as lowering lipids and preventing muscle atrophy. However, the impact of THB on PMOP has not been systematically explored. In vitro experiments supported that THB suppresses osteoclast formation and resorption of bone concentration-dependently. Further experiments confirmed that these inhibitory effects of THB were related to inhibition on expressions of osteoclast-specific genes, the mitogen-activated protein kinase (MAPK) pathway, and the nuclear factor kappa-B (NF-κB) pathway and an increased apoptosis level in mature osteoclasts. Additionally, THB treatment mitigated the ovariectomy-induced bone loss and improved the skeletal microarchitecture in vivo. In conclusion, THB has such potential to improve the PMOP status.

中文翻译：

四氢小檗碱通过抑制 RANKL 诱导的破骨细胞生成和促进破骨细胞凋亡来预防卵巢切除术引起的骨丢失

绝经后骨质疏松症 (PMOP) 是由雌激素缺乏引起的骨重塑破坏引起的，导致老年女性更容易发生骨质疏松性骨折。四氢小檗碱(THB)是从中药“浙江八味”系列中延胡索中提取的化合物，具有降血脂、防止肌肉萎缩等多种药理作用。然而，THB 对 PMOP 的影响尚未得到系统探讨。体外实验支持 THB 抑制破骨细胞形成和骨吸收，且呈浓度依赖性。进一步的实验证实，THB 的这些抑制作用与抑制破骨细胞特异性基因、丝裂原激活蛋白激酶 (MAPK) 途径和核因子 kappa-B (NF-κB) 途径的表达以及增加细胞凋亡水平有关。在成熟的破骨细胞中。此外，THB 治疗减轻了卵巢切除引起的骨质流失，并改善了体内骨骼微结构。总之，THB 有潜力改善 PMOP 状态。

更新日期：2024-09-05

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