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Biomimetic Peptide Nanonets: Exploiting Bacterial Entrapment and Macrophage Rerousing for Combatting Infections
ACS Nano ( IF 15.8 ) Pub Date : 2024-09-06 , DOI: 10.1021/acsnano.4c03669 Nan Gao 1 , Pengfei Bai 1 , Chunyang Fang 1 , Wanpeng Wu 1 , Chongpeng Bi 1 , Jiajun Wang 1 , Anshan Shan 1
ACS Nano ( IF 15.8 ) Pub Date : 2024-09-06 , DOI: 10.1021/acsnano.4c03669 Nan Gao 1 , Pengfei Bai 1 , Chunyang Fang 1 , Wanpeng Wu 1 , Chongpeng Bi 1 , Jiajun Wang 1 , Anshan Shan 1
Affiliation
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The alarming rise in global antimicrobial resistance underscores the urgent need for effective antibacterial drugs. Drawing inspiration from the bacterial-entrapment mechanism of human defensin 6, we have fabricated biomimetic peptide nanonets composed of multiple functional fragments for bacterial eradication. These biomimetic peptide nanonets are designed to address antimicrobial resistance challenges through a dual-approach strategy. First, the resulting nanofibrous networks trap bacteria and subsequently kill them by loosening the membrane structure, dissipating proton motive force, and causing multiple metabolic perturbations. Second, these trapped bacterial clusters reactivate macrophages to scavenge bacteria through enhanced chemotaxis and phagocytosis via the PI3K-AKT signaling pathway and ECM–receptor interaction. In vivo results have proven that treatment with biomimetic peptide nanonets can alleviate systemic bacterial infections without causing noticeable systemic toxicity. As anticipated, the proposed strategy can address stubborn infections by entrapping bacteria and awakening antibacterial immune responses. This approach might serve as a guide for the design of bioinspired materials for future clinical applications.
中文翻译：
仿生肽纳米网：利用细菌捕获和巨噬细胞再激活来对抗感染
全球抗菌药物耐药性的惊人上升凸显了对有效抗菌药物的迫切需求。受到人类防御素6的细菌截留机制的启发，我们制备了由多个功能片段组成的仿生肽纳米网，用于消灭细菌。这些仿生肽纳米网旨在通过双重方法策略应对抗菌素耐药性挑战。首先，由此产生的纳米纤维网络捕获细菌，随后通过松弛膜结构、耗散质子动力并引起多种代谢扰动来杀死细菌。其次，这些被捕获的细菌簇通过 PI3K-AKT 信号通路和 ECM-受体相互作用增强趋化性和吞噬作用，重新激活巨噬细胞以清除细菌。体内结果证明，仿生肽纳米网治疗可以减轻全身细菌感染，而不会引起明显的全身毒性。正如预期的那样，所提出的策略可以通过捕获细菌和唤醒抗菌免疫反应来解决顽固感染。这种方法可以作为未来临床应用的仿生材料设计的指南。
更新日期：2024-09-06
中文翻译：
仿生肽纳米网：利用细菌捕获和巨噬细胞再激活来对抗感染
全球抗菌药物耐药性的惊人上升凸显了对有效抗菌药物的迫切需求。受到人类防御素6的细菌截留机制的启发，我们制备了由多个功能片段组成的仿生肽纳米网，用于消灭细菌。这些仿生肽纳米网旨在通过双重方法策略应对抗菌素耐药性挑战。首先，由此产生的纳米纤维网络捕获细菌，随后通过松弛膜结构、耗散质子动力并引起多种代谢扰动来杀死细菌。其次，这些被捕获的细菌簇通过 PI3K-AKT 信号通路和 ECM-受体相互作用增强趋化性和吞噬作用，重新激活巨噬细胞以清除细菌。体内结果证明，仿生肽纳米网治疗可以减轻全身细菌感染，而不会引起明显的全身毒性。正如预期的那样，所提出的策略可以通过捕获细菌和唤醒抗菌免疫反应来解决顽固感染。这种方法可以作为未来临床应用的仿生材料设计的指南。
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