Development and validation of an imprinted polymer based DGT for monitoring β-blocker drugs in wastewater surveillance,Journal of Hazardous Materials

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Development and validation of an imprinted polymer based DGT for monitoring β-blocker drugs in wastewater surveillance
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2024-09-05 , DOI: 10.1016/j.jhazmat.2024.135753
Yanying Li ₁ , Mingzhe Wu ₁ , Xinyu Yin ₁ , Yansong Wang ₁ , Dongqin Tan ₁ , Peng Zhang ₂ , Zhimin Zhou ₃ , Degao Wang ₁ , Kevin C Jones ₄ , Hao Zhang ₄

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Wastewater surveillance is an effective and objective approach to monitor contaminant releases and drug usage in the catchment, the estimation requires accurate measurement. In this study, a novel diffusive gradients in thin-film (DGT) technique based on molecularly imprinted polymers (MIPs) for selective measurement of a class of widely prescribed cardiovascular drugs (β-blockers) in wastewater was developed. The synthesized MIPs showed strong affinity and selectivity for the target compounds. The MIP-DGT had large effective capacities, its performance was independent of a wide range of environmental conditions, including pH (4.58 – 8.89), ionic strength (0.01 – 0.5 M) and dissolved organic matter (< 20 mg L−1). Biofouling had little effect on the uptake of target compounds within 7 days. MIP-DGT devices were applied in a Chinese urban WWTP alongside an auto-sampler. Metoprolol concentrations detected were much higher than other β-blockers. Concentrations obtained using MIP-DGT were comparable to the 24 h composite samples using an autosampler. The estimated daily consumption calculated based on the data obtained with MIP-DGT implied that metoprolol and propranolol were the most popular β-blockers in the studied area. Overall, the results in this study demonstrate that the MIP-DGT is a cost-effective, reliable and efficient tool for in situ wastewater monitoring.

更新日期：2024-09-05

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