Near-Infrared-Light-Induced Iron(I) Dimer-Enabled Radical Cascade Reactions of Fluoroalkyl Bromides for the Synthesis of Ring-Fused Quinazolinones,Organic Letters

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Near-Infrared-Light-Induced Iron(I) Dimer-Enabled Radical Cascade Reactions of Fluoroalkyl Bromides for the Synthesis of Ring-Fused Quinazolinones
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-06 , DOI: 10.1021/acs.orglett.4c03087
Xiao-Di Su ₁ , Qiang Liu ₁ , Jin-Tang Cheng ₂ , Zhi-Xiang Wang _{1,

3} , Xiang-Yu Chen _{1,

3}

Affiliation

The use of an earth-abundant and inexpensive iron complex as a catalyst, coupled with near-infrared (NIR) light as the energy source, for radical reactions with alkyl halides has been far less developed. In this study, we report NIR light-mediated iron(I) dimer-catalyzed radical cascade reactions of fluoroalkyl bromides for the synthesis of ring-fused quinazolinones bearing a difluoromethyl group. In this process, the 3-bromo-1,10-phenanthroline ligand facilitates the reactivity of [CpFe(CO)₂]₂, thereby improving the efficiency of the reaction.

中文翻译：

近红外光诱导的铁(I)二聚体引发的氟代烷基溴自由基级联反应用于合成稠环喹唑啉酮

使用地球上丰富且廉价的铁配合物作为催化剂，结合近红外（NIR）光作为能源，与烷基卤化物进行自由基反应的开发还远远不够。在这项研究中，我们报道了近红外光介导的铁（I）二聚体催化的氟烷基溴自由基级联反应，用于合成带有二氟甲基的环稠合喹唑啉酮。在此过程中，3-溴-1,10-菲咯啉配体促进了[CpFe(CO) ₂ ] ₂的反应活性，从而提高了反应效率。

更新日期：2024-09-06

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