Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers,Alzheimer's & Dementia

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Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-09-06 , DOI: 10.1002/alz.14172
Anna M VandeBunte _{1,

2} , Hyunwoo Lee ₃ , Emily W Paolillo ₁ , Ging-Yuek Robin Hsiung ₃ , Adam M Staffaroni ₁ , Rowan Saloner ₁ , Carmela Tartaglia ₄ , Kristine Yaffe ₁ , David S Knopman ₅ , Eliana Marisa Ramos ₆ , Katya Rascovsky ₇ , Andrea C Bozoki ₈ , Bonnie Wong ₉ , Kimiko Domoto-Reilly ₁₀ , Allison Snyder ₁₁ , Peter Pressman ₁₂ , Mario F Mendez ₁₃ , Irene Litvan ₁₄ , Julie A Fields ₅ , Douglas R Galasko ₁₄ , Ryan Darby ₁₅ , Joseph C Masdeu ₁₆ , Maria Belen Pasqual ₁₆ , Lawrence S Honig ₁₇ , Nupur Ghoshal ₁₈ , Brian S Appleby ₁₉ , Ian R Mackenzie ₂₀ , Hilary W Heuer ₁ , Joel H Kramer ₁ , Adam L Boxer ₁ , Leah K Forsberg ₅ , Brad Boeve ₅ , Howard J Rosen ₁ , Kaitlin B Casaletto ₁ ,

Affiliation

Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Department of Psychology, Palo Alto University, Palo Alto, California, United States.
Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Tanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
David Geffen School of Medicine at UCLA, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, USA.
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
Harvard Massachusetts General Hospital Frontotemporal Disorders Unit, Charlestown, Massachusetts, USA.
Department of Neurology, University of Washington, Seattle, Washington, USA.
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
David Geffen School of Medicine at UCLA, Reed Neurological Research Center, Los Angeles, California, USA.
San Diego Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
Houston Methodist Neurological Institute, Houston, Texas, USA.
Department of Neurology, Irving Medical Center, Columbia University, New York, New York, USA.
Department of Neurology, St. Louis School of Medicine, Washington University, St. Louis, Missouri, USA.
Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life's Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).

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