Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX-AHF-2 trial,European Journal of Heart Failure

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Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX-AHF-2 trial
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-09-06 , DOI: 10.1002/ejhf.3451
Riccardo M Inciardi ₁ , Laura Staal ₂ , Beth Davison ₃ , Carlo M Lombardi ₁ , Douwe Postmus ₄ , Michael G Felker ₅ , Gerasimos Filippatos ₆ , Barry Greenberg ₇ , Peter S Pang ₈ , Piotr Ponikowski ₉ , Thomas Severin ₁₀ , Claudio Gimpelewicz ₁₀ , John Teerlink ₁₁ , Gad Cotter ₃ , Adriaan A Voors ₂ , Marco Metra ₁

Affiliation

Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Momentum Research and Inserm U942 MASCOT, Paris, France.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Duke University School of Medicine and Duke Clinical Research Institute, Durham, NC, USA.
Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Sulpizio Family Cardiovascular Center, University of California San Diego Health, La Jolla, CA, USA.
Department of Emergency Medicine, Indiana University, Indianapolis, IN, USA.
Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
Novartis Pharma, Basel, Switzerland.
Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California San Francisco, San Francisco, CA, USA.

Acute heart failure (AHF) is a major cause of hospitalizations and death in the elderly. However, elderly patients are often underrepresented in randomized clinical trials. We analysed the impact of age on clinical outcomes and response to treatment in patients enrolled in Relaxin in Acute Heart Failure (RELAX-AHF-2), a study that included older patients than in previous AHF trials.

中文翻译：

年龄对急性心力衰竭患者临床结局和对 serelaxin 反应的影响：RELAX-AHF-2 试验的分析

急性心力衰竭（AHF）是老年人住院和死亡的主要原因。然而，老年患者在随机临床试验中的代表性往往不足。我们分析了年龄对急性心力衰竭松弛素（RELAX-AHF-2）患者临床结局和治疗反应的影响，该研究纳入了比以前 AHF 试验更老年的患者。

更新日期：2024-09-06

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