Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A,ChemMedChem

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Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
ChemMedChem ( IF 3.6 ) Pub Date : 2024-09-05 , DOI: 10.1002/cmdc.202400500
Ingrid Wilt ₁ , Adrian Demeritte ₁ , Alexander Kim ₁ , Weiwei Wang ₂ , William M Wuest ₃

Affiliation

Ubiquinone mimics known as quinone outside inhibitors (QoIs) are one of the most prominent fungicides used to protect crops in the agricultural industry Due to the instability of the core features of the natural product peniciaculin A, synthesis of several simplified analogues was completed to probe the antifungal mechanism of action. Simplified analogues suggest the natural product peniciaculin A is inhibiting fungal growth through quinone outside inhibition. Analogues exhibited broad spectrum activity against fungal pathogens and demonstrated key features of known QoIs were required for activity.

中文翻译：

利用天然产品启发的抗真菌药研究青霉菌素 A 的作用机制

被称为醌外部抑制剂（QoI）的泛醌模拟物是农业中用于保护农作物的最突出的杀菌剂之一由于天然产物青霉菌素 A 的核心特征的不稳定性，完成了几种简化类似物的合成以探索抗真菌的作用机制。简化的类似物表明，天然产物青霉菌素 A 通过醌外抑制来抑制真菌生长。类似物对真菌病原体表现出广谱活性，并证明活性需要已知 QoI 的关键特征。

更新日期：2024-09-05

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