Neuromuscular impairment at different stages of human sarcopenia,Journal of Cachexia, Sarcopenia and Muscle

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Neuromuscular impairment at different stages of human sarcopenia
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2024-09-05 , DOI: 10.1002/jcsm.13531
Fabio Sarto ₁ , Martino V Franchi _{1,

2} , Jamie S McPhee ₃ , Daniel W Stashuk ₄ , Matteo Paganini ₁ , Elena Monti ₅ , Maira Rossi ₆ , Giuseppe Sirago _{1,

7} , Sandra Zampieri _{1,

2,

8} , Evgeniia S Motanova ₁ , Giacomo Valli ₁ , Tatiana Moro ₁ , Antonio Paoli ₁ , Roberto Bottinelli _{6,

9} , Maria A Pellegrino ₆ , Giuseppe De Vito _{1,

2} , Helen M Blau ₅ , Marco V Narici _{1,

2}

Affiliation

Degeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age-related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensively investigated in humans. This study aimed to compare neuromuscular system integrity and function at different stages of sarcopenia, with a particular focus on NMJ stability and MU properties.

中文翻译：

人类肌少症不同阶段的神经肌肉损伤

运动神经元和神经肌肉接头（NMJ）的退化以及运动单位（MU）的丧失会导致与年龄相关的肌肉萎缩和与肌肉减少症相关的无力。然而，这些特征尚未在人类身上得到全面研究。本研究旨在比较肌少症不同阶段的神经肌肉系统完整性和功能，特别关注 NMJ 稳定性和 MU 特性。

更新日期：2024-09-05

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