Ambient catalyst-free oxidation reactions of aromatic amines using water radical cations,Chemical Science

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Ambient catalyst-free oxidation reactions of aromatic amines using water radical cations
Chemical Science ( IF 7.6 ) Pub Date : 2024-09-06 , DOI: 10.1039/d4sc04519j
Xiaoping Zhang ₁ , Pinghua Hu ₁ , Minmin Duan ₁ , Konstantin Chingin ₂ , Roman Balabin ₂ , Xinglei Zhang ₁ , Huanwen Chen ₂

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Water radical cations play a pivotal role in various scientific and industrial fields due to their unique reactivity and capacity to drive complex chemical transformations. Here we explored the formation of quaternary ammonium cations through the direct oxidation reaction of aromatic amines, facilitated by water radical cations within water microdroplets. This process was monitored via in situ mass spectrometry and occurs under ambient conditions, negating the need for traditional chemical catalysts or oxidants and achieving an impressive yield of approximately 80%. Additionally, we employed a multi-channel spray system and enhanced both the reactant concentration and flow rate, thereby enabling gram-scale synthesis. These findings not only demonstrate the effectiveness and eco-friendliness of microdroplet chemistry but also provide a new understanding of heterogeneous ˙OH generation channels, thereby boosting the synthetic efficiency and sustainability of chemical processes.

中文翻译：

使用水自由基阳离子的芳香胺的环境无催化剂氧化反应

水自由基阳离子由于其独特的反应性和驱动复杂化学转化的能力，在各种科学和工业领域发挥着关键作用。在这里，我们探索了通过芳香胺的直接氧化反应形成季铵阳离子，并由水微滴中的水自由基阳离子促进。该过程通过原位质谱法进行监测，并在环境条件下发生，无需传统的化学催化剂或氧化剂，并实现了约 80% 的令人印象深刻的产率。此外，我们采用了多通道喷雾系统，提高了反应物浓度和流速，从而实现了克级合成。这些发现不仅证明了微滴化学的有效性和生态友好性，而且提供了对异质˙OH生成通道的新认识，从而提高了化学过程的合成效率和可持续性。

更新日期：2024-09-06

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