New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the mouse hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object-location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons in the superficial sublayer of the CA1 stratum pyramidale to whole-population activity. Applying hippocampal theta-driven closed-loop optogenetic suppression to mitigate this neuronal recruitment during (food-context) memory formation relaxed the topological constraint on hippocampal coactivity and restored subsequent flexible (object-location) memory. These findings uncover an organizational principle for the peer-to-peer coactivity structure of the hippocampal cell population to meet memory demands.

中文翻译：

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将海马体的协同结构从稳健记忆组织到灵活记忆


新的记忆被融入到先前的世界知识中。但是，如果连续的记忆对宿主大脑网络产生相反的要求怎么办？我们报告说，获得强大的（食物背景）记忆将小鼠海马体限制在高度相关的尖峰序列的群体活动空间内，从而阻止了灵活（物体位置）记忆的后续计算。这种紧密相关的放电结构是在重复的记忆经验中发展起来的，逐渐将 CA1 锥体层浅层的神经元与整个群体的活动耦合起来。应用海马θ驱动的闭环光遗传学抑制来减轻（食物背景）记忆形成过程中的神经元募集，放松了对海马协同活动的拓扑约束，并恢复了随后的灵活（物体位置）记忆。这些发现揭示了海马细胞群点对点协作结构满足记忆需求的组织原则。