Molar Mass Determination for Small and Large Molecules Using Diffusion-Ordered Spectroscopy,Analytical Chemistry

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Molar Mass Determination for Small and Large Molecules Using Diffusion-Ordered Spectroscopy
Analytical Chemistry ( IF 6.7 ) Pub Date : 2024-09-05 , DOI: 10.1021/acs.analchem.4c02874
Wolf Hiller ₁ , Bastian Grabe ₁ , Jan Schonert ₁

Affiliation

The development of the most comprehensive universal calibration of molar mass dependences will be presented. For the first time, diffusion-ordered spectroscopy (DOSY) can now provide structure-, solvent-, and temperature-independent molar mass determinations for both small and large molecules. This fundamental theoretical approach provides only one single function which could perfectly describe all molar mass dependences. The new development using DOSY was tested on 477 diffusion coefficients representing altogether 56 molar mass dependences of 30 small molecules in 7 solvents, 5 different polymers in 10 solvents, and 11 temperature dependences of 2 polymers in 2 solvents, respectively. These samples cover a very large range of molar masses varying between 70 g/mol until 1 200 000 g/mol. The derived equation for the molar masses delivered a very good accuracy for all samples and might be one of the best tools for molar mass determinations.

中文翻译：

使用扩散有序光谱法测定小分子和大分子的摩尔质量

将介绍最全面的摩尔质量依赖性通用校准的开发。现在，扩散有序光谱 (DOSY) 首次可以为小分子和大分子提供与结构、溶剂和温度无关的摩尔质量测定。这一基本理论方法仅提供一个可以完美描述所有摩尔质量依赖性的函数。使用 DOSY 的新开发成果在 477 个扩散系数上进行了测试，分别代表 7 种溶剂中 30 种小分子、10 种溶剂中 5 种不同聚合物的总共 56 种摩尔质量依赖性以及 2 种溶剂中 2 种聚合物的 11 种温度依赖性。这些样品的摩尔质量范围非常大，从 70 g/mol 到 1 200 000 g/mol。推导的摩尔质量方程为所有样品提供了非常好的精度，并且可能是摩尔质量测定的最佳工具之一。

更新日期：2024-09-05

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