BackgroundPrimary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by hyposalivation. Currently, there is limited evidence for the prognosis of dental implant treatment in Sjögren's syndrome.Aim/HypothesisWe hypothesized comparable clinical outcomes of implant‐supported restorations in pSS‐patients and control subjects, and improvement in oral health‐related quality of life 5 years after restoration.Material and MethodsPatients with pSS and matched (age, gender, and tooth region) control group were recruited between June 2016 and March 2020. The clinical and radiological examination were performed, and patient‐reported oral health impact profile (OHIP‐49) questionnaire was used 2 months (baseline), 1, 3, and 5 years after prosthetic treatment.ResultsWe included 23 patients with pSS and 24 matched control subjects (all women, mean age: 57.1 years). The overall DMFT (decayed‐missed‐filled‐tooth) was significantly higher (p = 0.008), symptoms of dry mouth were more severe (p = 0.001), and unstimulated and chewing‐stimulated saliva flow rates were significantly lower (p < 0.001) in pSS than in control group. All implants survived with no implant mobility. At implant sites, the plaque index and probing depths did not differ (p = 0.301 and 0.446, respectively), but the gingival index was significantly higher (p = 0.003) in pSS than control group. The mean marginal bone loss, prosthetic complications, and clinician‐reported aesthetic outcomes were similar in both groups after 5 years. The OHIP scores were significantly higher in the pSS than control group (p < 0.001) but reduced significantly in both groups (p = 0.026).ConclusionReplacement of missing single teeth with dental implants was successful in patients with pSS 5 years after restoration.

中文翻译：

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原发性干燥综合征患者单种植体支撑修复体的预后：一项为期五年的前瞻性临床研究


背景原发性干燥综合征（pSS）是一种以唾液分泌不足为特征的慢性全身性自身免疫性疾病。目前，关于干燥综合征牙种植体治疗预后的证据有限。目的/假设我们假设 pSS 患者和对照受试者的种植体支持修复体的临床结果具有可比性，并且 5 年后口腔健康相关生活质量得到改善材料和方法 2016 年 6 月至 2020 年 3 月期间招募 pSS 患者和匹配的（年龄、性别和牙齿区域）对照组患者。进行临床和放射学检查，并报告患者报告的口腔健康影响概况 (OHIP-49)在修复治疗后 2 个月（基线）、1 年、3 年和 5 年使用问卷。结果我们纳入了 23 名 pSS 患者和 24 名匹配的对照受试者（均为女性，平均年龄：57.1 岁）。总体 DMFT（蛀牙缺失补牙）显着较高（p = 0.008），口干症状更严重（p = 0.001），未刺激和咀嚼刺激的唾液流量显着较低（p <） pSS 中的值比对照组低 0.001)。所有植入物均存活且没有植入物移动性。在种植部位，pSS 组的菌斑指数和探测深度没有差异（分别为 p = 0.301 和 0.446），但牙龈指数显着高于对照组（p = 0.003）。 5 年后，两组的平均边缘骨丢失、假体并发症和临床医生报告的美学结果相似。 pSS 中的 OHIP 评分显着高于对照组 (p < 0.001)，但两组均显着降低 (p = 0.026)。结论 pSS 患者修复后 5 年单牙缺失的种植体是成功的。