Functional Amino Acids in the Regulation of Bone and Its Diseases,Molecular Nutrition & Food Research

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Functional Amino Acids in the Regulation of Bone and Its Diseases
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-09-05 , DOI: 10.1002/mnfr.202400094
Siying Li ₁ , Qinglu Tian ₁ , Liwei Zheng ₁ , Yachuan Zhou ₂

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Bone as a vigorous tissue is constantly undergoing bone remodeling. The homeostasis of bone remodeling requires combined efforts of multifarious bone cells. Amino acids (AA), known as essential components of life support, are closely related to the regulation of bone homeostasis. In recent years, the concept of functional amino acids (FAAs) has been proposed, which is defined as AA that regulate key metabolic pathways to improve health, survival, growth, development, lactation, and reproduction of organisms, to highlight their outstanding contributions in the body. In the hope of exploring new therapeutic strategies, this review focus on summarizing recent progress in the vital role of FAAs in bone homeostasis maintaining and potential implications of FAAs in bone-related diseases, and discussing related mechanisms. The results showed that FAAs are closely related to bone metabolism and therapeutic strategy targeting FAAs metabolism is one of the future trends for bone disorders, while the explorations about possible impact of FAAs-based diets are still limited.

中文翻译：

功能性氨基酸在骨骼及其疾病调控中的应用

骨骼作为一种有活力的组织，不断经历骨骼重塑。骨重塑的稳态需要多种骨细胞的共同努力。氨基酸（AA）被称为生命支持的重要组成部分，与骨稳态的调节密切相关。近年来，功能性氨基酸（FAA）的概念被提出，其定义为调节关键代谢途径以改善生物体的健康、生存、生长、发育、泌乳和繁殖的 AA，以突出它们在体内的突出贡献。为了探索新的治疗策略，本文重点总结了 FAAs 在维持骨稳态中的重要作用和 FAAs 在骨相关疾病中的潜在影响的最新进展，并讨论了相关机制。结果表明，FAAs 与骨代谢密切相关，靶向 FAAs 代谢的治疗策略是骨病的未来趋势之一，而对基于 FAAs 的饮食可能影响的探索仍然有限。

更新日期：2024-09-05

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