The most important predictor of bipolar disorder (BD) onset is a family history. Based on this premise, several offspring studies have recruited and followed offspring of parents with BD into early adulthood, including the Pittsburgh Bipolar Offspring Study, the Canadian Flourish Cohort, and the Dutch Bipolar Offspring Study (DBOS).1-3 These studies have shed important light on the incidence and prevalence of BD and other psychopathology in these offspring (11%-13% for BD-I/II), as well as the most important symptom-level and diagnostic predictors of BD in these youth.4 However, questions remains: what happens to these offspring as they reach middle adulthood? Do they continue to be at risk for BD and other mood disorders? These questions have critical clinical and research implications. Clinically, a better understanding of risk trajectories may inform monitoring, treatment, and our conversations with affected families. From a research perspective, a better understanding of the risk period informs the age range to in which to focus future efforts.

中文翻译：

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社论：患有双相情感障碍的父母的后代进入成年中期：与儿童精神科医生相关的风险窗口


双相情感障碍 (BD) 发病最重要的预测因素是家族史。基于这一前提，多项后代研究招募并追踪父母患有 BD 的后代进入成年早期，其中包括匹兹堡双相情感障碍后代研究、加拿大蓬勃发展队列和荷兰双相情感障碍后代研究 (DBOS)。1-3 这些研究已经揭示重要的是了解这些后代中 BD 和其他精神病理学的发病率和患病率（BD-I/II 为 11%-13%），以及这些青少年中 BD 最重要的症状水平和诊断预测因素。 4 然而，问题依然存在：这些后代到了中年时会发生什么？他们是否继续面临双相情感障碍和其他情绪障碍的风险？这些问题具有重要的临床和研究意义。在临床上，更好地了解风险轨迹可能有助于监测、治疗以及我们与受影响家庭的对话。从研究的角度来看，更好地了解风险期可以确定未来重点关注的年龄范围。