3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs,ACS Nano

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3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs
ACS Nano ( IF 15.8 ) Pub Date : 2024-09-04 , DOI: 10.1021/acsnano.4c08359
Tan Ye _{1,

2,

3,

4} , Muyuan Chai ₅ , Zhenxing Wang _{1,

2,

3,

4} , Tingru Shao ₆ , Ji Liu ₇ , Xuetao Shi _{1,

2,

3,

4}

Affiliation

Three-dimensionally printed (3DP) hydrogel-based vascular constructs have been investigated in response to the impaired function of blood vessels or organs by replicating exactly the 3D structural geometry to approach their function. However, they are still challenged by their intrinsic brittleness, which could not sustain the suture piercing and enable the long-term structural and functional stability during the direct contact with blood. Here, we reported the high-fidelity digital light processing (DLP) 3D printing of hydrogel-based vascular constructs from poly(vinyl alcohol)-based inks, followed by mechanical strengthening through engineering the nanocrystalline domains and subsequent surface modification. The as-prepared high-precision hydrogel vascular constructs were imparted with highly desirable mechanical robustness, suture tolerance, swelling resistance, antithrombosis, and long-term patency. Notably, the hydrogel-based bionic vein grafts, with precise valve structures, exhibited excellent control over the unidirectional flow and successfully fulfilled the biological functionalities and patency during a 4-week implantation within the deep veins of beagles, thus corroborating the promising potential for treating chronic venous insufficiency.

中文翻译：

具有工程纳米晶域的 3D 打印水凝胶作为功能性血管结构

人们已经研究了基于三维打印 (3DP) 水凝胶的血管结构，通过精确复制 3D 结构几何形状来接近其功能，以应对血管或器官功能受损的情况。然而，它们仍然受到其固有脆性的挑战，无法维持缝线刺穿并在与血液直接接触期间实现长期的结构和功能稳定性。在这里，我们报道了用聚（乙烯醇）基墨水对基于水凝胶的血管结构进行高保真数字光处理（DLP）3D打印，然后通过设计纳米晶域和随后的表面改性来进行机械强化。所制备的高精度水凝胶血管结构具有非常理想的机械坚固性、耐缝合性、抗膨胀性、抗血栓性和长期通畅性。值得注意的是，基于水凝胶的仿生静脉移植物具有精确的瓣膜结构，在比格犬深静脉植入 4 周期间，表现出对单向流动的出色控制，并成功实现了生物功能和通畅，从而证实了治疗慢性静脉功能不全。

更新日期：2024-09-04

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