Activatable Photoacoustic/Near-Infrared Probes for the Detection of Copper Ions of Cardiovascular Disease In Vivo and in Urine,ACS Sensors

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Activatable Photoacoustic/Near-Infrared Probes for the Detection of Copper Ions of Cardiovascular Disease In Vivo and in Urine
ACS Sensors ( IF 8.2 ) Pub Date : 2024-09-05 , DOI: 10.1021/acssensors.4c01490
Kai Wang _{1,

2} , Ke-Feng Gu ₁ , Jie Cao ₃ , Yu-Shun Yang ₂ , Hai-Liang Zhu ₂ , Jin-Hui Shang ₄ , Jie-Li Zhou ₅

Affiliation

Copper ions, implicated in processes such as oxidative stress and inflammation, are believed to play a crucial role in cardiovascular disease, a prevalent and deadly disease. Despite this, current diagnostic methods fail to detect early stage cardiovascular disease or track copper ion accumulation, limiting our understanding of the disease’s progression. Therefore, the development of noninvasive techniques to image copper ions in cardiovascular disease is urgently needed to enhance diagnostic precision and therapeutic strategies. In this study, we report the successful synthesis and application of a copper ion-activated photoacoustic probe, CS-Cu, which exhibits high sensitivity and selectivity toward copper ions both in vitro and in vivo. CS-Cu was able to noninvasively monitor the changes in copper ion levels and differentiate between different mice based on copper ions in urine. Furthermore, the probe demonstrated good photoacoustic stability and exhibited no significant toxicity in the mice. These findings suggest that CS-Cu could be a promising tool for early detection and monitoring of Cu²⁺ levels in vivo and urine, providing a new perspective on the role of copper ions in cardiovascular disease.

中文翻译：

用于检测体内和尿液中心血管疾病铜离子的可激活光声/近红外探针

铜离子与氧化应激和炎症等过程有关，被认为在心血管疾病（一种流行且致命的疾病）中发挥着至关重要的作用。尽管如此，当前的诊断方法无法检测早期心血管疾病或追踪铜离子的积累，限制了我们对疾病进展的了解。因此，迫切需要开发心血管疾病铜离子成像的无创技术，以提高诊断精度和治疗策略。在这项研究中，我们报道了铜离子激活光声探针CS-Cu的成功合成和应用，该探针在体外和体内对铜离子表现出高灵敏度和选择性。 CS-Cu能够无创地监测铜离子水平的变化，并根据尿液中的铜离子区分不同的小鼠。此外，该探针表现出良好的光声稳定性，并且在小鼠中没有表现出明显的毒性。这些发现表明CS-Cu可能成为早期检测和监测体内和尿液中Cu ²⁺水平的有前途的工具，为铜离子在心血管疾病中的作用提供了新的视角。

更新日期：2024-09-05

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