Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke,The New England Journal of Medicine

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Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
The New England Journal of Medicine ( IF 96.2 ) Pub Date : 2024-09-05 , DOI: 10.1056/nejmoa2314779
Opeolu Adeoye ₁ , Joseph Broderick ₁ , Colin P Derdeyn ₁ , James C Grotta ₁ , William Barsan ₁ , Oladi Bentho ₁ , Scott Berry ₁ , Mauricio Concha ₁ , Iris Davis ₁ , Stacie Demel ₁ , Jordan Elm ₁ , Nina Gentile ₁ , Todd Graves ₁ , Melissa Hoffman ₁ , Josephine Huang ₁ , James Ingles ₁ , Scott Janis ₁ , Adam S Jasne ₁ , Pooja Khatri ₁ , Steven R Levine ₁ , Aniel Majjhoo ₁ , Peter Panagos ₁ , Arthur Pancioli ₁ , Stephanie Pizzella ₁ , Tamra Ranasinghe ₁ , Noor Sabagha ₁ , Sanjeev Sivakumar ₁ , Christopher Streib ₁ , Achala Vagal ₁ , Alastair Wilson ₁ , Max Wintermark ₁ , Albert J Yoo ₁ , Andrew D Barreto ₁

Affiliation

From the Department of Emergency Medicine, Washington University, St. Louis (O.A., P.P., S.P.); the Departments of Neurology and Rehabilitation Medicine (J.B., I.D., S.D., M.H., P.K.), Emergency Medicine (A.P.), and Radiology (A.V.), University of Cincinnati, and the Department of Pharmacy, University of Cincinnati Medical Center (N.S.) - both in Cincinnati; the Department of Radiology, University of Virginia, Charlottesville (C.P.D.); the Clinical Institute for Research and Innovation, Memorial Hermann Hospital (J.C.G.), the Department of Neuroradiology, University of Texas M.D. Anderson Cancer Center (M.W.), and the Department of Neurology, University of Texas Health Science Center (A.D.B.), Houston, Berry Consultants, Austin (S.B., T.G.), and the Texas Stroke Institute, Medical City Healthcare, Dallas (A.J.Y.) - all in Texas; the Department of Emergency Medicine, University of Michigan, Ann Arbor (W.B.), and the Department of Neurology, McLaren Flint, Flint (A.M.) - both in Michigan; the Department of Neurology, University of Minnesota, Minneapolis (O.B., C.S.); the Department of Neurology, Sarasota Memorial Hospital, Intercoastal Medical Group, Sarasota (M.C.), and the Department of Neurology, Mayo Clinic, Jacksonville (J.H.) - both in Florida; the Department of Public Health Sciences, Medical University of South Carolina, Charleston (J.E., J.I.), and the Department of Medicine (Neurology), Prisma Health-Upstate, University of South Carolina Greenville School of Medicine, Greenville (S.S.); the Department of Emergency Medicine, Temple University, Philadelphia (N.G.); the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (S.J.); the Department of Neurology, Yale University, New Haven, CT (A.S.J.); the Departments of Neurology and Emergency Medicine, State University of New York, New York (S.R.L.); the Department of Neurology, Wake Forest University, Winston-Salem, NC (T.R.); and the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.W.).

Intravenous thrombolysis is a standard treatment of acute ischemic stroke. The efficacy and safety of combining intravenous thrombolysis with argatroban (an anticoagulant agent) or eptifibatide (an...

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