Immunological studies in trans-individuals undergoing gender affirming hormone therapy,Nature Reviews Immunology

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Immunological studies in trans-individuals undergoing gender affirming hormone therapy
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-09-04 , DOI: 10.1038/s41577-024-01070-0
Anna James ₁ , Petter Brodin _{1,

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Affiliation

Personalized medicine for all requires a shift in science and clinical culture that puts more emphasis on the sources of inter-individual variation. Important examples are sex differences in the presentation and severity of diseases, as well as in responses to therapy. Understanding the mechanisms that drive these differences is important in the context of individualized healthcare, and also to better understand the immune sequelae of long-term sex hormone supplementation or inhibition in transgender individuals. Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences of long-term sex-hormone supplementation on immunity in transgender individuals.

中文翻译：

接受性别肯定激素治疗的跨性别者的免疫学研究

面向所有人的个性化医疗需要科学和临床文化的转变，更加重视个体差异的来源。重要的例子是疾病的表现和严重程度以及对治疗的反应方面的性别差异。了解导致这些差异的机制对于个体化医疗保健非常重要，并且对于更好地了解跨性别个体长期补充或抑制性激素的免疫后遗症也很重要。免疫力的性别特异性差异是由遗传和激素决定的。本评论讨论了长期补充性激素对跨性别者免疫力影响的初步见解。

更新日期：2024-09-04

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