Extract

P2X3 receptors are found on sensory nerves and are activated by ATP. The recent discovery that P2X3 antagonism is effective in treating patients with refractory chronic cough has prompted recent studies into the effects of inhaled ATP [1–4], but few data exist pertaining to its safety and tolerability. We recently studied inhaled ATP in healthy volunteers, identifying adverse effects not previously reported.

中文翻译：

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健康志愿者吸入 ATP 后支气管收缩

 提炼

P2X3 受体存在于感觉神经上并被 ATP 激活。最近发现 P2X3 拮抗剂可有效治疗难治性慢性咳嗽患者，这促使最近对吸入 ATP 的影响进行研究 [1-4]，但有关其安全性和耐受性的数据很少。我们最近对健康志愿者进行了吸入 ATP 的研究，发现了以前未报道过的不良影响。