Sarcopenia, a prevalent condition, significantly impacts the prognosis of patients with decompensated cirrhosis (DC). Serum fibroblast growth factor 21 (FGF21) levels are significantly higher in DC patients with sarcopenia. Satellite cells (SCs) play a role in aging- and cancer-induced sarcopenia. Here, we investigated the roles of FGF21 and SCs in DC-related sarcopenia as well as the underlying mechanisms.

中文翻译：

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在失代偿性肝硬化中，肝脏分泌的 FGF21 通过 klotho beta 抑制卫星细胞肌生成来诱导肌肉减少症


肌肉减少症是一种常见疾病，它显着影响失代偿性肝硬化 (DC) 患者的预后。患有肌少症的 DC 患者血清成纤维细胞生长因子 21 (FGF21) 水平显着升高。卫星细胞（SC）在衰老和癌症引起的肌少症中发挥着重要作用。在这里，我们研究了 FGF21 和 SC 在 DC 相关肌肉减少症中的作用及其潜在机制。