The correction of protein folding is fundamental for cellular functionality and its failure can lead to severe diseases. In this context, molecular chaperones are crucial players involved in the tricky process of assisting in protein folding, stabilization, and degradation. Chaperones, such as heat shock proteins (HSP) 90, 70, and 60, operate within complex systems, interacting with co-chaperones both to prevent protein misfolding and direct to the correct folding.

中文翻译：

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陪伴系统：调节囊性纤维化中 CFTR 表达的有趣靶标


蛋白质折叠的纠正对于细胞功能至关重要，其失败可能导致严重的疾病。在这种情况下，分子伴侣是参与协助蛋白质折叠、稳定和降解的棘手过程的关键参与者。伴侣蛋白，如热休克蛋白 (HSP) 90、70 和 60，在复杂的系统中运作，与辅助伴侣相互作用，既防止蛋白质错误折叠，又引导正确的折叠。